The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)
- Volume 16 Issue 2
- /
- Pages.119-137
- /
- 2003
- /
- 1738-6640(pISSN)
- /
- 2234-4020(eISSN)
The Immunosuppressive Effect of Younggaechulgam-tang through Inhibition of Nuclear Translocation of Transcription Factor
전사인자의 핵 전이 억제를 통한 영계출감탕의 면역 억제 효과
Abstract
Younggaechulgam-tang has been used for treating skin diseases. In this study, I investigated the immunosuppressive effect of Younggaechul-tang in the human T cell line MOLT-4 cells. MOLT-4 cells were stimulated with the phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (PMA) + A23187. The secretion appeared to be greater when cells were stimulated with PHA than with PMA + A23187. Younggaechulgam-tang had no affect proliferation stimulated by PHA. I showed that IL-2 secretion and expression by PHA stimulated MOLT-4 cells were inhibited by Younggaechugam-tang treatment. Maximal inhibition rate of IL-2, TNF-
Keywords