Inhibitory Effect on Melanogenesis of Rhizoma Bletillae

白급이 멜라닌 형성 억제에 미치는 영향

  • 윤화정 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 윤정원 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 윤소원 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 고우신 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 우원홍 (원광대학교 한의과대학 병리학교실)
  • Published : 20030800


Recently many efforts were focused to understand the mechanical insights of melanogenesis to develop the agents for hyper-pigmentation and hypo-pigmentation. In the melanin biosynthetic pathway, tyrosinase is the rate limiting enzyme, and ${\alpha}$-melanocyte stimulating hormone(MSH) or cAMP-elevating agents stimulate melanogenesis and enhance the melanin synthesis and the tyrosinase activity. The author has analyzed the effects of Rhizoma Bletillae on the basal melanogenic activities of B16 mouse melanoma cells. Rhizoma Bletillae alone markedly suppressed melanin content and tyrosinase activity in a dose-dependent manner. Pretreatment of the cells with Rhizoma Bletillae. The decrease in the tyrosinase activity was paralled by a decrease in the abundance of tyrosinase protein and tyrosinase promoter activity. These results suggest that Rhizoma Bletillae inhibits melanogenesis of B16 melanoma cells via suppression of tyrosinase activity.