Association between Tardive Dyskinesia and T103C Polymorphisms of 5-$HT_{2A}$ Receptor Gene

지연성 운동장애와 5-$HT_{2A}$ 수용체 유전자 T103C 다형성과의 관계

  • Hahn, Sang Woo (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
  • Shin, Jeong Won (Department of Laboratory Medicine, College of Medicine, Soonchunhyang University Hospital) ;
  • Choi, Tae Youn (Department of Laboratory Medicine, College of Medicine, Soonchunhyang University Hospital) ;
  • Woo, Sung Il (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
  • Jung, Han Yong (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
  • Jung, Hee Yeoun (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
  • Han, Sun Ho (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital)
  • 한상우 (순천향대학교 의과대학 서울병원 신경정신과학교실) ;
  • 신정원 (순천향대학교 의과대학 서울병원 임상병리과학교실) ;
  • 최태윤 (순천향대학교 의과대학 서울병원 임상병리과학교실) ;
  • 우성일 (순천향대학교 의과대학 서울병원 신경정신과학교실) ;
  • 정한용 (순천향대학교 의과대학 부천병원 신경정신과학교실) ;
  • 정희연 (순천향대학교 의과대학 천안병원 신경정신과학교실) ;
  • 한선호 (순천향대학교 의과대학 서울병원 신경정신과학교실)
  • Published : 2003.11.30

Abstract

Objective:Some candidate gene polymorphisms were reported to be associated with tardive dyskinesia (TD). The aim of this study was to investigate the association of the 5-$HT_{2A}$ receptor gene polymorphisms with TD in Korean schizophrenic subjects. Method:Subjects were of 59 schizophrenic patients with TD and 60 schizophrenic patients without TD for studying of 5-$HT_{2A}$ receptor gene polymorphisms. TD was evaluated using the Abnormal Involuntary Movement Scale(AIMS). Genomic DNA was amplified by PCR and digestion with MspI and BsmI. Result:There were no statistically significant differences in the demographic variables, such as age, male to female percentage, duration of illnesses and duration of antipsychotic drug exposure between the TD group and control group. 1) T102C polymorphisms and TD Comparing the TD group and control group, the 102T/C allele was associated with a significantly increased risk for TD (${\chi}^2$=5.560, df=1, p=0.018). 2) Three AIMS categories of TD and T102C genotype. There were statistically significant differences in the three AIMS categories(${\chi}^2$=6.835, df=2, p=0.033). Conclusion:These result suggest 102T/C genotypes of the 5-$HT_{2A}$ receptor gene are related to the development of TD. The 102T/C genotypes were associated with significantly higher AIMS orofacial dyskinesia scores. These findings suggest that the 5-$HT_{2A}$ receptor gene is significantly associated with susceptibility to TD in patients with chronic schizophrenia.

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