생물정신의학 (Korean Journal of Biological Psychiatry)
- 제10권2호
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- Pages.121-125
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- 2003
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
양극성 장애 환자에서 Apo-1/Fas Promoter 유전자 다형성
Association of a Polymorphism in the Promoter Region of Apo-1/Fas Gene with Bipolar Disorder
- 김규현 (경희대학교 의과대학 고황의학연구소) ;
- 손소정 (국립서울병원) ;
- 이희제 (경희대학교 의과대학 고황의학연구소) ;
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김종우
(경희대학교 의과대학 고황의학연구소) ;
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정주호
(경희대학교 의과대학 고황의학연구소)
- Kim, Kyu Hyun (Kohwang Medical Research Institute, College of Medicine, Kyunghee University) ;
- Son, So-Jeong (Seoul National Hospital) ;
- Lee, Hee Jae (Kohwang Medical Research Institute, College of Medicine, Kyunghee University) ;
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Kim, Jong Woo
(Kohwang Medical Research Institute, College of Medicine, Kyunghee University) ;
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Chung, Joo-Ho
(Kohwang Medical Research Institute, College of Medicine, Kyunghee University)
- 발행 : 2003.11.30
초록
Objective:Recently, many experimental evidences have been reported that psychiatric diseases are closely related with neurodevelopmental abnormalities and this can be properly explained by apoptosis. It is known that Apo-1/Fas is one of the genes in charge of apoptosis related with neurodevelopmental abnormalities. In this study, the association between bipolar disorder and functional polymorphism in Apo-1/Fas promoter gene has been investigated. Method:For 81 bipolar disorder patients and 217 healthy control subjects, MvaI restriction fragment length polymorphism(RFLP) of Apo-1/Fas promoter gene was analyzed after polymerase chain reaction(PCR) amplification. Result:There was a statistical significant difference in genotypic distribution(