Korean Journal of Biological Psychiatry (생물정신의학)
- Volume 10 Issue 2
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- Pages.116-120
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- 2003
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
Genetic Polymorphisms of Apolipoprotein E in Korean Schizophrenic Patients
한국인 정신분열병 환자에서 Apolipoprotein E 유전자의 다형성
- Cho, Gwang-Hyun (Department of Psychiatry, College of Medicine, Chonbuk National University) ;
- Chung, Sang-Geun (Department of Psychiatry, College of Medicine, Chonbuk National University) ;
- Hwang, Ik-Keun (Department of Psychiatry, College of Medicine, Chonbuk National University)
- Published : 2003.11.30
Abstract
Objectives:Although polymorphisms of apolipoprotein E have been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the genotypes of apolipoprotein E in schizophrenia and healthy controls, and to compare them in two groups in terms of distribution of apolipoprotein E genotype and allele. Method:Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotypes were identified in 77 schizophrenics and 115 healthy control persons. Results:The results were as follows 1) When genotypes of apolipoprotein E were classified into