Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Four Cases of Scrub Typhus Treated with Azithromycin in Children

소아에서 발생한 쯔쯔가무시 열에서 Azithromycin 치료 완치 4례

  • Kim, Eun Jung (Department of Pediatrics, Wonkwang University, School of Medicine) ;
  • Lee, Chang Yoo (Department of Pediatrics, Wonkwang University, School of Medicine) ;
  • Oh, Yeon Gyun (Department of Pediatrics, Wonkwang University, School of Medicine) ;
  • Yun, Hyang Suk (Department of Pediatrics, Wonkwang University, School of Medicine) ;
  • Kim, Jong Duck (Department of Pediatrics, Wonkwang University, School of Medicine)
  • 김은정 (원광대학교 의과대학 소아과학교실) ;
  • 이창우 (원광대학교 의과대학 소아과학교실) ;
  • 오연균 (원광대학교 의과대학 소아과학교실) ;
  • 윤향석 (원광대학교 의과대학 소아과학교실) ;
  • 김종덕 (원광대학교 의과대학 소아과학교실)
  • Received : 2002.07.04
  • Accepted : 2002.10.09
  • Published : 2003.02.15
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Abstract

Tsutsugamushi fever is a serious febrile disease outwardly similar to malaria and various arboviral infections. The endemic area is Asia-Pacific. This disease are generally associated with disturbed habitats favoring large populations of vector larval trombiculid mites. Therapy with tetracycline, chloramphenicol or ciprofloxacin is currently recommanded. Unfortunately these drugs is suboptimal for children and pregnant women. Recently, azithromycin has been proven to be effective in therapy of scrub typhus. There is no evidence that azithromycin causes adverse reaction to developing fetus or children. We report four cases of tsutsugamushi fever in children successfully treated with azithromycin. This is the first report describing clinical application of azithromycin to tsutsugamushi fever in Korean children.

저자들은 발열, 피부발진, 물린 부위의 가피(eschar) 등을 주소로 내원하여, 혈청학적으로도 쯔쯔가무시 열로 확진된 소아에서 5일 동안의 azithromycin 투약으로 특별한 합병증 없이 완치된 4례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

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