Clinical and Experimental Pediatrics
- Volume 46 Issue 2
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- Pages.183-187
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- 2003
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- 2713-4148(eISSN)
Analysis of Affecting Factors for Cortisol Level in Cord Blood
제대혈 Cortisol 농도에 영향을 미치는 인자에 대한 연구
- Lim, Hyun Jung (Department of Obstetrics and Gynecology, College of Medicine, Chosun University) ;
- Song, Chang Hun (Department of Obstetrics and Gynecology, College of Medicine, Chosun University) ;
- Kim, Eun Young (Department of Pediatrics, College of Medicine, Chosun University) ;
- Park, Sang Kee (Department of Pediatrics, College of Medicine, Chosun University)
- 임현정 (조선대학교 의과대학 산부인과학교실) ;
- 송창훈 (조선대학교 의과대학 산부인과학교실) ;
- 김은영 (조선대학교 의과대학 소아과학교실) ;
- 박상기 (조선대학교 의과대학 소아과학교실)
- Received : 2002.10.16
- Accepted : 2002.11.09
- Published : 2003.02.15
Abstract
Purpose : Long-term stress to the fetus causes alterations in adrenal steroidogenesis. The purpose of this study was to analyze the association of cord blood cortisol with stress during delivery. Methods : Cord blood samples were collected from 58 neonates at once to labor. Cortisol was measured by RIA method(DPC, USA). Cortisol level according to gestational age(<34, 34-37, >38 wks) and method of delivery(Cesarean section vs. vaginal delivery), Apgar score and uterine contraction, were compared to know stress during labor. Results : Cortisol of cord blood had considerable differences between each group, according to gestational age(P<0.001). It was statistically higher in the cases of vaginal delivery than cessarian delivery(P<0.001). The concentration of cortisol was significantly higher according to duration of labor (P<0.05). There was a significant relationship between cortisol level and uterine contraction(P<0.05). The concentration of cortisol was significantly low when Apgar score at 1 min was low(P<0.05). Conclusion : Cord cortisol has close association with stress during labor. And so do with post birth prognosis of neonate.
목 적 : 태아시기의 장기간 스트레스는 부신의 호르몬 합성에 영향을 미치는 것으로 알려져 있다. 분만 동안의 급성 스트레스와 제대혈 코티솔간의 상관관계를 보고자 본 연구를 시행하였다. 방 법 : 총 58명의 신생아를 대상으로 분만 즉시 제대혈을 10 mL 채취하였고,