대한수의학회지 (Korean Journal of Veterinary Research)

  • 제43권3호
  • /
  • Pages.317-322
  • /
  • 2003
  • /
  • 2466-1384(pISSN)
  • /
  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지

출생 후 몽골리안 저빌의 후각망울과 기저핵에서 TrkA의 분포

The Distribution of TrkA in the Olfactory Bulb and Basal Nucleus of the Mongolian Gerbil after Birth

  • Hou, Xilin (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Il-kwon (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Kyung-youl (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Mi-sun (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Sang-keun (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Kang-yi (College of Oriental Medicine, Daejeon University) ;
  • Lee, Geun-jwa (Chungnam Livestock & Veterinary Service Institute) ;
  • Kim, Moo-kang (College of Veterinary Medicine, Chungnam National University)
  • 심사 : 2003.06.25
  • 발행 : 2003.09.25
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

TrkA is an essential component of the high affinity NGF receptor necessary to the mediate biological effects of the neurotrophins NGF. Here we report on the expression of TrkA in the olfactory bulb and basal nucleus of Mongolian gerbil brain during the postnatal development. The expressions of TrkA were identified in a immunohistochemical method. Higher levels of TrkA immunoreactivity were detected in septum than that in olfactory bulb and caudate putamen (CPu). But TrkA was not observed before postnatal days (PND6) in olfactory bulb and PND9 in CPu. No TrkA-positive cell was detectable in the olfactory fiber layer. Several regions, such as olfactory bulb and CPu, showed weak labeling. These data show that expression of TrkA is developmentally regulated during postnatal Mongolian gerbil brain development and suggest that high affinity neurotrophinreceptors mediate a transient response to neurotrophins in many regions during the brain ontogeny.

키워드

참고문헌

  1. Ayer-LeLievre, C., Olson, L., Ebendal, T., Seiger, A. and Persson, H. Expression of the $\beta$-nerve growth factor gene in hippocampal neurons. Science. 1988, 240, 1339-1341
  2. Banerjee, S. P., Anyder, S. H., Cuatrecasas, P. and Greene, L. A. Binding of nerve growth factor receptor in sympathetia ganglia. Proc. Natl. Acad. Sci. USA. 1973, 70, 2519-23
  3. Bitaoshi, I. and Dexamethasone, M. Induces TrkA and p75NTR Iinmunoreactivity in the Cerebral Cortex and Hippocampus. Exp. Neurol. 2000, 162, 257-267
  4. Ebendal, T. NGF in CNS: experimental data and clinical implications. Prog. Growth Factor Res. 1989, 1, 143-159
  5. Ernfors, P., Gbendal, T., Olson, L., Mouton, P., Stromberg, I. and Person, H. Cell line producing recombinant nerve growth factor evokes grovtth responses in intrinsic and grafted central cholinergic neurons Proc. Natl. Acad. Sci. USA 1989, 86, 4756-4760
  6. Greene, L., Burstein, D. and Black, M. The role of transcription-dependent priming in nerve growth factor- promoted neurite outgrowth. Dec. Biol. 1982, 91, 305-316
  7. Greene, L. and Shooter, E. Nerve growth factor: biochemistry, synthesis and mechanism of action. Annu. Rev. Biochem. 1980, 3, 353-402
  8. Gunderson, R. W. and Barrett, J. N. Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor. Science. 1979, 206, 1079-1080
  9. Haleroua, S. and Patrick, J. Nerve growth factor mediates phosphorylation of specific proteins. Cell 1980, 22, 571-581
  10. Hefti, F. Nerve growth factor promotes survival of septal cholinergie neurons after fimbrial transactions. J. Neurosci. 1986, 346, 2155-2162
  11. Herrup, K. and Shooter, E. M. Properties of the B-nerve growth factor receptor of avian dorsal root ganglia. Pro. Natl. Acad. Sd. USA 1973, 70, 3884-3888
  12. Kaplan, D. R., Hemstead, B. L., Martin, Z. D., Chao, M. V. and Parada, L. F. The TrK proto-oncogene product: a signal transducting receptor for nerve growth factor, Science 1991, 252, 554-558
  13. Kaplan, D. R., Martin-Zanca, D. and Parada, L. F. Tyrosine Phosphorylation and tyrosine kinase activity of the TrK proto-oncogene product induced by NGF. Nature 1991, 350, 158-160
  14. Leonard, D., Ziff, E. and Greene, L. Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells. Mol. Cell. Biol. 1987, 7, 3156-3167
  15. Levi-MontaIcini, R. Developmental neurobiology and ths natural history of nerve growth factor. Rev. Neurosci. 1982, 5, 341-362
  16. Levi-Montalcini, R. The nerve growth factor:thirty-five years later. Embo. J. 1987, 6, 1145-1154
  17. Narumi, S. and Fujita, T. Stimulatory effects of substance P and nerve growth factor (NGF) on neurite outgrowth in embryonic chick dorsal root ganglia. Neuropharmaco. 1978, 1, 73-76
  18. Thoenen, H., Brandtlow, C. and Heumann, R. The physiological function of nerve growth factor in the central nervous system: comparison with the periphery. Rev. Physiol. Biochem. Pharmacol. 1987, 109, 146-178
  19. Thomas, R., Hugo, L. and Hakan, P. Expression of Members of trk family in the developing postnatal rat brain. Develop. Brain Res. 1993, 72, 119-131
  20. Yanker, B. and Shoote, E. The biology and mechanism of action of nerve growth factor. Annu. Rev. Biochem. 1982, 51, 845-868
  21. Yu M, Tolson N, Guroff G, et al. Increased phosphorylation of specific nuclear proteins in superior cervical ganglia and PC12 cells in response to nerve growth factor. J. Biol. Chem. 1980, 255, 10481-10492