Journal of the Korean Academy of Clinical Electrophysiology (대한임상전기생리학회지)
- Volume 1 Issue 1
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- Pages.45-56
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- 2003
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- 1738-0472(pISSN)
Iontiophoretic Transdermal Delivery of Triamcinolone Acetonide on Delayed Onset Muscle Soreness
지연성 근육통에 대한 Triamcinolone Acetonide의 이온도입 경피투과
- Jung, Dae-In (Dept. of Physical Therapy, Dasung Clinic) ;
- Kim, Myong-Hoon (Dept. of Physical Therapy, Kwangju Health College) ;
- Hwang, Tae-Yeun (Dept. of Physical Therapy, Chunnam Techno College) ;
- Yoon, Se-Won (Dept. of Physical Therapy, Pohang Medical Center) ;
- Choi, Eun-Young (Dept. of Occupational Therapy, Kwangyang Health College)
- Published : 2003.09.30
Abstract
This study investigated the effects of triamcinolone acetonide by iontophoretic transdermal drug delivery on anti-inflammatory action into the human which had excentric exercise-induced delayed onset muscle soreness in the non-dominant arm. The degree of anti-inflammation was evaluated creatine posphokinase(CPK) by serum enzyme activity and subjective pain threshold by soreness muscle scale in clinical study. The results Were as follows; 1. In a subjective pain scale, all groups showed non-significant difference but, showed a tendency to decrease numerical value in human. 2. In the serum CPK level, iontophoresis group showed more significant reduction than other groups at 24, 48 and 72 hours. From the results, the iontophoresis with triamcinolone acetonide is more effective than using each groups. The continuous study is needed for many interesting issues of iontophoretic transdermal drug delivery in new future.