IMMUNE NETWORK
- 제3권1호
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- Pages.69-77
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- 2003
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Cyclooxygenase-2 Specific Inhibitor (SC-58635)가 Lipopolysaccharide로 자극한 대식세포에서 Nitric Oxide와 Prostaglandin E2 생산에 미치는 영향
Effect of Cyclooxygenase-2 Specific Inhibitor (SC-58635) on the Production of Nitric Oxide and Prostaglandin E2 in Lipopolysaccharide-stimulated Macrophage Cells
- 홍승재 (경희대학교 의과대학 내과학교실) ;
- 양형인 (경희대학교 의과대학 내과학교실) ;
- 윤휘중 (경희대학교 의과대학 내과학교실) ;
- 이명수 (원광대학교 의과대학 내과학교실) ;
- 강효종 (분당제생병원 내과) ;
- 김완욱 (가톨릭대학교 의과대학 내과학교실) ;
- 이상헌 (가톨릭대학교 의과대학 내과학교실) ;
- 조철수 (가톨릭대학교 의과대학 내과학교실) ;
- 김호연 (가톨릭대학교 의과대학 내과학교실)
- Hong, Seung-Jae (Department of Internal Medicine, Kyung-Hee University Medical College) ;
- Yang, Hyung-In (Department of Internal Medicine, Kyung-Hee University Medical College) ;
- Yoon, Hwi-Joong (Department of Internal Medicine, Kyung-Hee University Medical College) ;
- Lee, Myoung-Soo (Department of Internal Medicine, Won-Kwang University Medical College) ;
- Kang, Hyo-Jong (Department of Internal Medicine, Daejin Medical Center) ;
- Kim, Wan-Uk (Department of Internal Medicine, Catholic University Medical College) ;
- Lee, Sang-Heon (Department of Internal Medicine, Catholic University Medical College) ;
- Cho, Chul-Soo (Department of Internal Medicine, Catholic University Medical College) ;
- Kim, Ho-Youn (Department of Internal Medicine, Catholic University Medical College)
- 발행 : 2003.03.30
초록
Background: Celecoxib, a COX-2 specific inhibitor, has recently been used for the treatment of rheumatoid arthritis. However, the molecular and cellular mechanisms of celecoxib against RA inflammation remain to be defined. To elucidate the action mechanism of celecoxib on inflammatory cells, we investigated the effect of celecoxib on the production of two important mediators of inflammation, nitric oxide and PGE2 Methods: RAW 264.7 cells stimulated with LPS were preincubated with various concentrations of celecoxib (from