IMMUNE NETWORK
- Volume 3 Issue 1
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- Pages.29-37
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- 2003
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
CCR7 Ligands Induced Expansion of Memory CD4+ T Cells and Protection from Viral Infection
CCR7 Ligand의 Memory CD4+ T 세포 증가유도 및 바이러스 감염에 대한 방어효과
- Eo, Seong-Kug (Department of Microbiology, College of Veterinary Medicine and Bio-Safety Institute of Chonbuk National University) ;
- Cho, Jeong-Gon (Department of Microbiology, College of Veterinary Medicine and Bio-Safety Institute of Chonbuk National University)
- Published : 2003.03.30
Abstract
Background: CC chemokine receptor (CCR) 7 and cognate CCR7 ligands, CCL21 (formerly secondary lymphoid tissue chemokine [SLC]) and CCL19 (formerly Epstein-Barr virus-induced molecule 1 ligand chemokine [ELC]), were known to establish microenvironment for the initiation of immune responses in secondary lymphoid tissue. As described previously, coadministration of DNA vaccine with CCR7 ligand-encoding plasmid DNA elicited enhanced humoral and cellular immunity via increasing the number of dendritic cells (DC) in secondary lymphoid tissue. The author hypothesized here that CCR7 ligand DNA could effectively expand memory CD4+ T cells to protect from viral infection likely via increasing DC number. Methods: To evaluate the effect of CCR7 ligand DNA on the expansion of memory CD4+ T cells, DO11.10.BALB/c transgenic (Tg)-mice, which have highly frequent ovalbumin