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The Korean Association of Immunobiologists (대한면역학회)
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Immune Stimulating Efficacy of Soluble β-1,3-glucans

수용성 β-1,3-glucans의 면역 활성 효능에 대한 연구

  • Shim, Jung-Hyun (Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology) ;
  • Choi, Won-A (DMJ Biotech Crop.) ;
  • Kim, Jong-Wan (Dankook University School of Medicine) ;
  • Lee, Hae-Sook (Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology) ;
  • Baek, Tae-Woong (Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology) ;
  • Cho, Min-Cheol (Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Kyung-Ae (Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology) ;
  • Sang, Byung-Chan (Department of Dairy Science, ChungNam National University) ;
  • Yoon, Do-Young (Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology)
  • 심정현 (한국생명공학연구원 세포생물학연구실) ;
  • 최원아 ((주)더멋진 바이오텍) ;
  • 김종완 (단국대학교 의과대학) ;
  • 이해숙 (한국생명공학연구원 세포생물학연구실) ;
  • 백태웅 (한국생명공학연구원 세포생물학연구실) ;
  • 조민철 (한국생명공학연구원 세포생물학연구실) ;
  • 이경애 (한국생명공학연구원 세포생물학연구실) ;
  • 상병찬 (충남대학교 낙농학과) ;
  • 윤도영 (한국생명공학연구원 세포생물학연구실)
  • Published : 2003.06.30
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Abstract

Background: $\beta$-1,3-glucans are well known to enhance the immune reactions, resulting in antitumor, antibacterial, antiviral, anticoagulatory and wound healing activities. $\beta$-1, 3-glucans have various activities depending on molecular weight, degree of branching, conformation, water-solubility and intermolecular association. However, the $\beta$-1,3-glucan linked backbone structure is essential and $\beta$-D-glucopyranosyl units are required for immuno-potentiating activities. Result: In this study, we tested the immunophamacological activities of soluble $\beta$-1,3-glucans and confirmed the following activities: (1) $IFN-{\gamma}$ production in PBMCs in the presence or the absence of PHA, LPS, or IL-18; (2) induction of various cytokines in the spleen and thymus; (3) adjuvant effect on the antibody production; (4) nitrogen oxide synthesis in macrophages; (5) the cytotoxic and antitumor effects on cell lines and ICR mice. Conclusion: These results strongly suggested that $\beta$-1,3-glucans possessed various immuno-pharmacological activities.

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