IMMUNE NETWORK
- 제3권3호
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- Pages.211-218
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- 2003
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
다용량 비타민 C 투여가 생쥐 세포매개면역반응에 미치는 영향
The Effects of High-dose Vitamin C Administration on the Cell-mediated Immune Response in Mice
- 노가화 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터) ;
- 김헌곤 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터) ;
- 신영아 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터) ;
- 임현자 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터) ;
- 문성규 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터) ;
- 이용택 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터) ;
- 이왕재 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터) ;
- 이동섭 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터) ;
- 황영일 (서울대학교 의과대학 해부학교실, 종양면역의과학연구센터)
- Noh, Kahwa (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine) ;
- Kim, Heun-gon (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine) ;
- Shin, Young-ah (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine) ;
- Lim, Hyunja (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine) ;
- Mun, Sung-kyu (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine) ;
- Lee, Yongtaek (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine) ;
- Lee, Wang Jae (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine) ;
- Lee, Dongsup (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine) ;
- Hwang, Young-il (Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine)
- 발행 : 2003.09.30
초록
Background: Vitamin C is an essential nutrient, taken as a daily supplement by many people. Recently, high-dose vitamin C is considered as a therapeutic regimen in some clinical situations. Until now, few studies have been done with the effects of high-dose vitamin C on the immune response. Methods: In this experiment, the effects of high-dose vitamin C on cell-mediated immune response in immunologically competent mice were evaluated. After intraperitoneal injection of 2.5, 5, or 10 mg/day of vitamin C for 10 days, delayed type hypersensitivity (DTH) was provoked against DNFB in the pinnae as a model for cell-mediated immune response. Severity of DTH reaction was evaluated as the thickness of pinnae, and the vitamin C levels were measured in the serum, liver, kidney, lung, pinnae, and splenocytes. Results: After challenge, the thickness increased at its peak on the