Journal of Acupuncture Research
- Volume 20 Issue 3
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- Pages.1-14
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- 2003
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
Preventive Effect on Development of Diabetes and Renoprotective Effect of Acanthopanax Senticosus Aqua-acupuncture in Multiple Low-dose Streptozotocin-Induced Diabetic Rats
가시오가피약침(五加皮藥鍼)이 당뇨유발억제(糖尿誘發抑制) 및 신장보호활성(腎臟保護活性)에 미치는 영향
- Chung, Chong-un (Department of Acupuncture & Moxibustion, College of Oriental Medicine Kyung-Hee University) ;
- Lee, Yun-ho (Department of Acupuncture & Moxibustion, College of Oriental Medicine Kyung-Hee University) ;
- Kang, Sung-keel (Department of Acupuncture & Moxibustion, College of Oriental Medicine Kyung-Hee University)
- Received : 2003.03.22
- Accepted : 2003.05.17
- Published : 2003.06.20
Abstract
Objective : The aim of the study was to investigate the preventive effect of Acanthopanax senticosus(AS) aqua-acupuncture into Sinsu(BL23) of the multiple low-does strepozotocin(STZ)-induced diabetic rats. Methods : The experimental animals were divided into 4 groups : normal group of rats, control group of multiple low-does STZ-induced diabetic rats, NSAA group with 0.4ml normal saline(NS) aqua-acupunctured subcutaneously into Sinsu in multiple low-does STZ-induced diabetic rats, and ASAA group with 0.4ml of 20% AS aqua-acupunctured subcutaneously into Sinsu in multiple low-does STZ-induced diabetic rats. Each of AS and NS aqua-acupuncture was done subcutaneously into both loci of Sinsu taking turns everyday for 3 weeks. Thereafter the levels of serum glucose, body weight, index of kidney hypertrophy, urine glucose, urinary albumin excretion, creatinine clearance, mesangial cell and TGF-