Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Scavenging Effect on NO, DPPH and Inhibitory Effect on IL-4 in Astragali Radix Herbal-Acupuncture Solution

황기약침액(黃耆藥鍼液)의 NO, DPPH 소거(消去) 및 IL-4 억제효과(抑制效果)

  • Lee, Kyung-min (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-San University) ;
  • Seo, Jung-chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-San University) ;
  • Han, Sang-won (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-San University)
  • 이경민 (경산대학교 한의과대학 침구경혈학교실) ;
  • 서정철 (경산대학교 한의과대학 침구경혈학교실) ;
  • 한상원 (경산대학교 한의과대학 침구경혈학교실)
  • Received : 2003.03.13
  • Accepted : 2003.03.22
  • Published : 2003.04.20
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Abstract

Objective : This study was designed fo find out whether Astragali Radix Herbal-Acupuncture Solution(ARHA) can scavenge NO, DPPH and IL-4 or not. Astragali Radix has been clinically used to reforce the depression of immune reponse etc. in Oriental Medicine. Methods : Free radical metabolism seems to occupy a remarkably common position in the mechanisms of ageing and ageing related disease. Oxidative damage to DNA, lipids, proteins and other molecules may contribute to the development of cancer, cardiovascular disease and possibly neurodegenerative disease. The effects of ARHA on NO, DPPH and IL-4 were measured. Results : The followings are the summary of the result; (1) There is a significant scavenging effect of ARHA on NO in 1, $10mg/m{\ell}$ group in after 24hrs. (2) There is no significant scavenging effect of ARHA on DPPH. (3) There is a significant scavenging effect of ARHA on IL-4 in 1, $10,100{\mu}g/m{\ell}$ group. Conclusions : These results suggest that ARHA has significant scavenging effect on NO, IL-4 and not on DPPH. This study shows that ARHA can be used for ageing related disease and further studies are required to investigate the antioxidative effects of it.

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