Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Acupoint combination-related changes of NADPH-d diaphorase and neuronal nitric oxide synthase in the brainstem and cerebellum of spontaneously hypertensive rats

족삼리(足三里) 경혈배합(經穴配合)에 따른 SHR의 뇌줄기, 소뇌(小腦) 영역(領域)에서 NADPH-diaphorase와 nNOS, 신경세포(神經細胞)의 변화연구(變化硏究)

  • Lee, Hong-min (Department of Acupuncture and Moxibustion College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Chang-hwan (Department of Acupuncture and Moxibustion College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Yong-suk (Department of Acupuncture and Moxibustion College of Oriental Medicine, Kyung-Hee University)
  • 이홍민 (경희대학교 한의과대학 침구학교실) ;
  • 김창환 (경희대학교 한의과대학 침구학교실) ;
  • 김용석 (경희대학교 한의과대학 침구학교실)
  • Received : 2003.09.09
  • Accepted : 2003.09.20
  • Published : 2003.12.20
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Abstract

Objective: This study examines the effects of acupoint combination on NADPH-diaphorase and neuronal nitric oxide synthase(nNOS) in the brainstem of spontaneously hypertensive rats. Methods: The changes of NADPH-d-positive neurons using a histochemical method and the changes of nNOS-positive neurons using an immunohistochemical method were evaluated. The optical densities of NADPH-d-positive neurons and nNOS-positive neurons of the Choksamni(ST36) Umnungchon(SP9) groups were significantly increased in all brainstem areas as compared to the Choksamni and Choksamni Kokchi(LI11) groups and decreased, with the exeption of the nNOS-positive neurons in the superficial gray of superior colliculus, as compared to the normal group. Results: Our results demonstrated that electroacupuncture changes the activity in the NO system in the brainstem of SHR and the acupoint combination is one of the important parameters for this effect.

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