Tuberculosis and Respiratory Diseases
- Volume 54 Issue 5
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- Pages.495-509
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- 2003
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
Decreased Neutrophil Apoptosis in Patients with Sepsis is Related to the Activation of NF-κB
패혈증 환자에서 NF-κB 활성화에 의한 호중구 아포프토시스의 억제
- Kwon, Sung Youn (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University, College of Medicine, Clinical Research Institute, Seoul National University Hospital, Lung Institute, Medical Research Center, Seoul National University) ;
- Lee, Choon-Taek (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University, College of Medicine, Clinical Research Institute, Seoul National University Hospital, Lung Institute, Medical Research Center, Seoul National University) ;
- Kim, Young Whan (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University, College of Medicine, Clinical Research Institute, Seoul National University Hospital, Lung Institute, Medical Research Center, Seoul National University) ;
- Han, Sung Koo (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University, College of Medicine, Clinical Research Institute, Seoul National University Hospital, Lung Institute, Medical Research Center, Seoul National University) ;
- Shim, Young-Soo (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University, College of Medicine, Clinical Research Institute, Seoul National University Hospital, Lung Institute, Medical Research Center, Seoul National University) ;
- Yoo, Chul-Gyu (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University, College of Medicine, Clinical Research Institute, Seoul National University Hospital, Lung Institute, Medical Research Center, Seoul National University)
- 권성연 (서울대학교 의과대학 내과학교실, 서울대학교병원 의학연구소, 서울대학교 의학연구원 폐연구소) ;
- 이춘택 (서울대학교 의과대학 내과학교실, 서울대학교병원 의학연구소, 서울대학교 의학연구원 폐연구소) ;
- 김영환 (서울대학교 의과대학 내과학교실, 서울대학교병원 의학연구소, 서울대학교 의학연구원 폐연구소) ;
- 한성구 (서울대학교 의과대학 내과학교실, 서울대학교병원 의학연구소, 서울대학교 의학연구원 폐연구소) ;
- 심영수 (서울대학교 의과대학 내과학교실, 서울대학교병원 의학연구소, 서울대학교 의학연구원 폐연구소) ;
- 유철규 (서울대학교 의과대학 내과학교실, 서울대학교병원 의학연구소, 서울대학교 의학연구원 폐연구소)
- Published : 2003.05.30
Abstract
Background : Neutrophil-mediated inflammation is usually self-limiting, because neutrophils have a remarkably short life span. Prolonged neutrophil survival, which is caused by decreased spontaneous apoptosis, leads to persistent inflammation in sepsis. Because many inflammatory cytokines, which generate signals that delay apoptosis, are regulated by nuclear factor-
연구배경 : 호중구에 의해 매개되는 염증반응은 호중구의 수명이 매우 짧기 때문에 대부분 자연 종결된다. 패혈증에서는 이러한 호중구의 아포프토시스가 감소되어 수명이 연장되어 있어서 지속적인 염증반응이 일어나게 된다. 호중구의 수명 연장을 유도하는 많은 염증 매개 물질들이 nuclear factor-