Journal of Yeungnam Medical Science
- 제20권2호
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- Pages.187-196
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- 2003
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- 2799-8010(eISSN)
근골격계 종양에서 사이토카인 발현의 분석
The Analysis of the Cytokine Expression in Musculoskeletal Tumors
- 이준한 (영남대학교 의과대학 정형외과학교실) ;
- 곽은석 (영남대학교 의과대학 정형외과학교실) ;
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손욱진
(영남대학교 의과대학 정형외과학교실) ;
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김희선
(영남대학교 의과대학 미생물학교실) ;
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신덕섭
(영남대학교 의과대학 정형외과학교실)
- Lee, Joon-Han (Department of Orthopaedic Surgery, College of Medicine, Yeungnam University) ;
- Kwak, Eun-Seok (Department of Orthopaedic Surgery, College of Medicine, Yeungnam University) ;
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Shon, Oog-Jin
(Department of Orthopaedic Surgery, College of Medicine, Yeungnam University) ;
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Kim, Hee-Sun
(Department of Microbiology, College of Medicine, Yeungnam University) ;
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Shin, Duk-Seop
(Department of Orthopaedic Surgery, College of Medicine, Yeungnam University)
- 발행 : 2003.12.30
초록
The cytokines are the hormone-like proteins, which are produced in the mononuclear cells. They have many roles, such as immune mediators, cell differentiations, angiogenesis. The chemokines have chemotactic effects which control the host immune response. There were few reports about the cytokines associated with musculoskeletal tumors. From late 1980s, the cytokine studies of bone tumors such as osteosarcoma were started, but most studies for benign and malignant musculoskeletal tumors were left to be explored. To evaluate the characteristics of the cytokines in variable musculoskeletal tumors, tissues were obtained from the seven patients who visited the Yeungnam University hospital from February to July 2000. They were lipoma (1 case), parosteal osteoma (1 case), enchondroma (2 cases), pigmented villonodular synovitis (1 case), ganglion (1 case), and metastaic squamous cell carcinoma (1 case). The gene experession of the cytokines were analyzed by RNase protection assay (RPA) and reverse transcription-polymerase chain reaction (RT-PCR). The lipoma and parosteal osteoma expressed MIP-