Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Histologic findings of three-wall intrabony defects around dental implants using different grafting materials in beagle dogs

수종의 골이식재를 이용한 성견의 임플란트 주위 3면 골내낭의 조직학적 관찰

  • Moon, Hee-Il (Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Moon, Sang-Kwon (Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Shim, Chang-sung (Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Shim, Jung-Sung (Department of Prosthodontics, College of Dentistry, Yonsei university) ;
  • Lee, Yong-Keun (Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University) ;
  • Cho, Kyu-Sung (Department of Periodontology, Research Institute for Periodontal regeneration, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • 문희일 (연세대학교 치과대학 치주과학교실) ;
  • 문상권 (연세대학교 치과대학 치주과학교실) ;
  • 김창성 (연세대학교 치과대학 치주과학교실) ;
  • ;
  • 이용근 (연세대학교 치과대학 치과생체재료공학교실) ;
  • 조규성 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소, BK21의과학사업단) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소, BK21의과학사업단)
  • Published : 2003.09.30
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Abstract

연구목적 : SLA surface dental implant 주위의 3면 골내낭에서 xenogeneic demineralized bone matric putty, porous ${\beta}$-tri-calcium phosphate, 새로이 개발된 non-crystalline calcium phosphate glass를 사용한 치료를 조직학적으로 비교 평가하기 위한 것이다. 연구방법 : 실험동물로는 15개월에서 18개월 사이의 12kg에서 15kg 정도되는 성견을 사용하였다. 20개의 SLA surface implant가 사용되었으며, 성견 하악의 양측에 각각 2개씩 사용되었다. 임플란트 식립전에, 각각의 임플란트 근심면에 straight fissure bur를 이용하여 표준화된 3면 골내앙(근원심 5mm ${\times}$협설 3mm ${\times}$깊이 3mm)을 형성하였다. 형성된 골 결손부에는 demineralized bone matrix putty, porous ${\beta}$-tri-calcium phosphate, non-crystalline calcium phosphate glass를 넣은 것을 각각 실험군으로, 이식재를 넣지 않은 것을 대조군으로 사용하였다. 8주 후에 실험 동물을 희생시키고 조직학적 관찰을 하였다. 결과 : 조직학적 소견상 임플란트 주위에 급성 염증 소견은 보이지 않았으며, non-crystalline calcium phosphate glass은 매우 적은량의 신생골을, ${\beta}$-TCP을 이용한 골내낭에서는 약간의 기저부에서 유래된 신생골이 관찰된다. ${\beta}$-TCP granules 가운데로 상당량의 측면의 골에서 유래된 신생골 형성이 보인다. xenogeneic DBM putty에서는 많은 량의 신생골이 기저부에 형성된 것을 볼수 있으나 대조군과의 차이는 크지 않다. 이식재의 종류와 상관없이 흡수되지 않은 이식재를 임플란트 주위에서 관찰할 수 있었다. 골내낭 안의 이식재들은 모두 connective tissue로 둘러 싸여 있었다. 모든 실험군에서 이식재에서 기인한 신생골 형성과 임플란트 표면에 신생 골유착의 조직학적 증거는 발견되지 않았다.

Keywords

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