Journal of Periodontal and Implant Science

  • 제33권3호
  • /
  • Pages.341-348
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  • 2003
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
권호 표지

Cefuroxime axetil의 치주병원성 세균에 대한 최소억제농도와 치은열구액 농도에 관한 실험적 연구

GCF concentration and minimal inhibitory concentration of cefuroxime axetil against periodontopathogens

  • 장현선 (조선대학교 치과대학 치주과학교실, 조선대학교 구강생물학연구소) ;
  • 김재덕 (조선대학교 치과대학 치주과학교실) ;
  • 국중기 (조선대학교 치과대학 구강생화학교실, 조선대학교 구강생물학연구소) ;
  • 김화숙 (조선대학교 치과대학 구강생화학교실, 조선대학교 구강생물학연구소) ;
  • 유소영 (조선대학교 치과대학 구강생화학교실, 조선대학교 구강생물학연구소) ;
  • 김미광 (조선대학교 치과대학 구강생화학교실, 조선대학교 구강생물학연구소) ;
  • 김병옥 (조선대학교 치과대학 치주과학교실, 조선대학교 구강생물학연구소)
  • Jang, Hyun-Seon (Department of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Kim, Jae-Duk (Department of Periodontology, College of Dentistry, Chosun University) ;
  • Kook, Joong-Ki (Department of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Kim, Hwa-Sook (Department of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • You, So-Young (Department of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Kim, Mi-Kwang (Department of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Kim, Byung-Ock (Department of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University)
  • 발행 : 2003.09.30
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초록

The purpose of this study was to determine the minimal inhibitory concentration (MIC) of cefuroxime axetil,　semisynthetic cefalosporin, for some putative periodotopathogens; F. nucleatum, A. actinomycetemcomitans P. intermedia and P. gingivalis. To investigate the efficacy of cefuroxime axetil, several antibiotics, amoxicillin, metronidazole, and ciprofoxacine, were used as control. The MIC was measured by Murray' s method. The MIC of cefuroxime axetil against some putative microbes, as a single use regimen, was relatively high in comparison with that of the other antibiotics used in this study. The MIC of cefuroxime axetil/metronidazole against some putative microbes, as a simultaneous regimen, was similar to that of the other antibiotics used in this study. The manimal level of cefuroxime concentration in gingival fluid was 9${\mu}$/ml at 36hr after the first dose. In conclusion, within the limited experiment, metronidazole/ cefuroxime axetil therapy of periodontitis may provide a therapeutic benefits in reducing the periodontopathogens.

키워드

참고문헌

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