Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Degradation rate of several types of Calcium Polyphosphate;Long term results

다양한 형태의 다공질 Calcium Polyphosphate의 생분해성에 관한 장기적인 연구

  • Yang, S.M. (Dept. of Periodontology, College of Dentistry, Seoul National University, Dept. of Periodontology Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Seol, Y.J. (Dept. of Periodontology, College of Dentistry, Seoul National University, Dept. of Periodontology Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Kye, S.B. (Dept. of Periodontology, College of Dentistry, Seoul National University, Dept. of Periodontology Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Lee, I.K. (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
  • Lee, C.W. (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
  • Kim, S.Y. (School of Materials Engineering, Yeungnam University) ;
  • Lee, Yong-Mu (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
  • Ku, Y. (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
  • Han, S.B. (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
  • Chung, C.P. (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
  • Choi, S.M. (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
  • Rhyu, I.C. (Dept. of Periodontology, College of Dentistry, Seoul National University, Dept. of Periodontology Samsung Medical Center, School of Medicine, Sungkyunkwan University)
  • 양승민 (서울대학교 치과대학 치주과학교실, 성균관대학교 의과대학 치과학교실) ;
  • 설양조 (서울대학교 치과대학 치주과학교실, 성균관대학교 의과대학 치과학교실) ;
  • 계승범 (서울대학교 치과대학 치주과학교실, 성균관대학교 의과대학 치과학교실) ;
  • 이인경 (서울대학교 치과대학 치주과학교실) ;
  • 이철우 (서울대학교 치과대학 치주과학교실) ;
  • 김석영 (영남대학교 공과대학 재료금속공학부) ;
  • 이용무 (서울대학교 치과대학 치주과학교실) ;
  • 구영 (서울대학교 치과대학 치주과학교실) ;
  • 한수부 (서울대학교 치과대학 치주과학교실) ;
  • 정종평 (서울대학교 치과대학 치주과학교실) ;
  • 최상묵 (서울대학교 치과대학 치주과학교실) ;
  • 류인철 (서울대학교 치과대학 치주과학교실, 성균관대학교 의과대학 치과학교실)
  • Published : 2003.06.30
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Abstract

The purpose of this study is to evaluate the biocompatibility and the biorsorbability of several types of calcium polyphosphate made through change of manufacturing process for 12 month. To solve limitation of calcium phosphate, we developed a new ceramic, Calcium Polyphosphate(CPP), and report the biologic response to CPP in extraction sites of beagle dog. Porous CPP blocks were prepared by condensation of anhydrous $Ca(H_2PO_4)_2$ to form non-crystalline $Ca(PO_3)_2$ and then milled to produce CPP powder. CPP powder, CPP block, and CPP granules added with $Na_2O$ were implanted in extraction sockets and histologic observation were performed at 12 months later. Like 3 months results, histologic observation at 12 months revealed that CPP matrix were mingled with and directly apposed to new bone without any adverse tissue reaction, CPP powder show direct bony contact, but new bone formation and fibrous tissue encapsulation showed in CPP block. 10% $Na_2O$ CPP granules show more inflammatory cells infiltration around graft materials compared at 3 month, but 15% $Na_2O$ CPP granules show less. This result revealed that regardless of addition of $Na_2O$, CPP had a high affinity for bone and had been resorbed slowly. From this results, it was suggested that CPP is promising ceramic as a bone substitute and addition of $Na_2O$ help biodegradation but optimal concentration of $Na_2O$ and other additive component to increase degradation rate should be determined in further study.

Keywords

References

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