Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Clinical Efficacy of Toothpaste Containing Chitosan;Multicenter study

키토산 함유 치약의 임상적 효과;Multicenter study

  • Kim, Min-Kyoung (Department of periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration Brain Korea 21 project for medical science) ;
  • Choi, Seong-Ho (Department of periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration Brain Korea 21 project for medical science) ;
  • Shin, Seung-Yun (Department of periodontology, College of dentistry, Seoul National University) ;
  • Rhyu, In-Chul (Department of periodontology, College of dentistry, Seoul National University) ;
  • Herr, Yeek (Department of periodontology, College of dentistry, Kyung Hee University) ;
  • Park, Joon-Bong (Department of periodontology, College of dentistry, Kyung Hee University) ;
  • Cho, Kyoo-Sung (Department of periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration Brain Korea 21 project for medical science)
  • 김민경 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소, BK21 의과학 사업단) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소, BK21 의과학 사업단) ;
  • 신승윤 (서울대학교 치과대학 치주과학교실) ;
  • 류인철 (서울대학교 치과대학 치주과학교실) ;
  • 허익 (경희대학교 치과대학 치주과학교실) ;
  • 박준봉 (경희대학교 치과대학 치주과학교실) ;
  • 조규성 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소, BK21 의과학 사업단)
  • Published : 2003.06.30
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Abstract

Many researches are being done to study the effect of toothpaste containing natural extracts. The aim of this study was to evaluate the plaque control effect and therapeutic effect of toothpaste products containing chitosan extract. 120 healthy subjects with gingivitis or early periodontitis were divided into two groups. Subjects in the experimental group only used toothpaste containing chitosan and subjects in the control group used toothpaste without chitosan. At first, subjects received scaling and tooth brushing instruction. Gingival index, bleeding index, probing pocket depth, probing attachment level were scored at baseline, 2 months, and 3 months, and plaque index were scored at baseline, 1 month, 2 months, 3 months. Gingival index of experimental group and control group at baseline, 2 months, and 3 months use were 0.71${\pm}$0.66, 0.49${\pm}$0.55, 0.36${\pm}$0.49 and 0.62${\pm}$0.58, 0.51${\pm}$0.52, 0.48${\pm}$0.50 (mean${\pm}$SD), respectively (statistically significant different at p <0.05 ). Plaque index of experimental group and control group at baseline, 1 month, 2 months, and 3 months were 0.52${\pm}$0.50, 0.43${\pm}$0.50, 0.39${\pm}$0.49, 0.29${\pm}$0.46 and 0.49${\pm}$0.50, 0.50${\pm}$0.50, 0.51${\pm}$0.50, 0.45${\pm}$0.50, respectively (statistically significant different at p<0.05 ). Bleeding index of experimental group and control group were 0.40${\pm}$0.49, 0.33${\pm}$0.47, 0.24${\pm}$0.43 and 0.40${\pm}$0.49,0,38${\pm}$0.49,0.30${\pm}$0.46, respectively (statistically significant different at p<0.05). Probing depth of experimental group and control group were 2.41${\pm}$0.64, 2.31${\pm}$0.60, 2.28${\pm}$0.55 and 2.51${\pm}$0.67, 2.47${\pm}$0.63,2.42${\pm}$0.62, respectively (statistically significant different at p${\pm}$0.66, 2.32${\pm}$0.62 and 2.54${\pm}$0.70, 2.51${\pm}$0.69,2.46${\pm}$0.66, respectively (statistically significant different at p<0.05 ). From these finding, it can be concluded that toothpaste containing chitosan have better plaque control effect and therapeutic effect on gingivitis and early periodontitis compared to conventional toothpastes.

Keywords

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