Journal of Periodontal and Implant Science

  • 제33권1호
  • /
  • Pages.13-26
  • /
  • 2003
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
권호 표지

생분해성 Calcium Metaphosphate골이식재의 골조직재생효과에 관한 연구

The effect of calcium metaphosphate bone graft materials on bone regeneration

  • 채한승 (서울대학교 치과대학 치주과학교실) ;
  • 이용무 (서울대학교 치과대학 치주과학교실) ;
  • 양승민 (서울대학교 치과대학 치주과학교실, 성균과대학교 의과대학 치과학교실) ;
  • 천성수 (영남대학교 공과대학 재료공학교실) ;
  • 김석영 (영남대학교 공과대학 재료공학교실) ;
  • 구영 (서울대학교 치과대학 치주과학교실) ;
  • 정종평 (서울대학교 치과대학 치주과학교실) ;
  • 한수부 (서울대학교 치과대학 치주과학교실) ;
  • 최상묵 (서울대학교 치과대학 치주과학교실) ;
  • 류인철 (서울대학교 치과대학 치주과학교실)
  • Chae, Han-seung (Department of Periodontology, Graduate School, Seoul National University) ;
  • Lee, Yong-Moo (Department of Periodontology, Graduate School, Seoul National University) ;
  • Yang, Seung-Min (Department of Periodontology, Graduate School, Seoul National University, Department of Dentistry, College of Medicine, Sungkyunkwan University) ;
  • Chun, Sung-Soo (School of Material Science, College of Engineering, Youngnam University) ;
  • Kim, Suk-Young (School of Material Science, College of Engineering, Youngnam University) ;
  • Ku, Young (Department of Periodontology, Graduate School, Seoul National University) ;
  • Choung, Chong-Pyoung (Department of Periodontology, Graduate School, Seoul National University) ;
  • Han, Soo-Boo (Department of Periodontology, Graduate School, Seoul National University) ;
  • Choi, Sang-Mook (Department of Periodontology, Graduate School, Seoul National University) ;
  • Rhyu, In-Chul (Department of Periodontology, Graduate School, Seoul National University)
  • 발행 : 2003.03.30
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초록

Periodontal regeneration therapy with bone-substituting materials has gained favorable clinical efficacy by enhancing osseous regeneration in periodontal bony defect. As bone-substituting materials, bone powder, calcium phosphate ceramic, modified forms of hydroxyapatite, and hard tissue replacement polymer have demonstrated their periodontal bony regenerative potency. Bone-substituting materials should fulfill several requirements such as biocompatibility, osteogenecity, malleability, biodegradability. The purpose of this study was to investigate biocompatibility, osteo-conduction capacity and biodegradability of $Na_2O$, $K_2O$ added calcium metaphosphate(CMP). Beta CMP was obtained by thermal treatment of anhydrous $Ca_2(H_2PO_4)_2$. $Na_2O$ and $K_2O$ were added to CMP. The change of weight of pure CMP, $Na_2O$-CMP, and $K_2O$-CMP in Tris-buffer solution and simulated body fluid for 30 days was measured. Twenty four Newzealand white rabbits were used in negative control, positive control(Bio-Oss), pure CMP group, 5% $Na_2$-CMP group, 10% $Na_2O$-CMP goup, and 5% $K_2O$-CMP group. In each group, graft materials were placed in right and left parietal bone defects(diameter 10mm) of rabbit. The animals were sacrificed at 3 months and 6 months after implantation of the graft materials. Degree of biodegradability of $K_2O$ or $Na_2O$ added CMP was greater than that of pure CMP in experimental condition. All experimental sites were healed with no clinical evidence of inflammatory response to all CMP implants. Histologic observations revealed that all CMP grafts were very biocompatible and osseous conductive, and that in $K_2O$-CMP or $Na_2O$-CMP implanted sites, there was biodegradable pattern, and that in site of new bone formation, there was no significant difference between all CMP group and DPBB(Bio-Oss) group. From this result, it was suggested that all experimental CMP group graft materials were able to use as an available bone substitution.

키워드

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