디-2-피리딜케톤을 이용한 산성의약품 선택성 막전극의 특성

Potentiometric Characteristics of Acidic Drug Selective membrane Electrodes using Di-2-pyridyl ketone

  • 투고 : 2003.03.20
  • 심사 : 2003.07.08
  • 발행 : 2003.08.25

초록

산성의약품의 선택성 액체막 전극을 전기활성물질로서 di-2-pyridyl ketone (DPK)-금속-산성의약품간의 삼성분착물로 제조하였다. 금속이온은 $Fe^{2+}$, $Co^{2+}$, $Ni^{2+}$, $Cu^{2+}$ 등을 사용하였고, 가소제는 니트로페닐에텔계를 사용하였다. 메페남산 선택성 막 전극은 pH 8.9의 붕산 완충용액중에서 그리고 이부프로펜 선택성 막 전극은 pH 7.0의 인산 완충용액 중에서 각각 $5{\times}10^{-5}{\sim}10^{-3}mol/L$ 농도에서 검정선이 얻어졌다. 메페남산 및 이부프로펜 표준품 일정량 첨가에 의한 회수율을 측정한 결과는 99.0%와 98.4%이었고 상대표준편차는 각각 2.4%와 2.6%이었다.

Acidic drug selective electrodes based on metal(II)-di-2-pyridyl ketone-acidic drugs ternary complex as electroactive material were prepared. The metal ions, $Fe^{2+}$, $Co^{2+}$, $Ni^{2+}$, $Cu^{2+}$ were used. Nitrophenyl ether series were used as plasticizers. The electrodes exhibit a fast stable and linear response for $5{\times}10^{-5}{\sim}10^{-3}mol/L$ mefenamic acid (MA) in borate buffer solution (pH 8.9) and ibuprofen(Ib) in phosphate buffer solution (pH 7.0). The recovery test for mefenamic acid and ibuprofen using standard addition method were 99.0% and 98.4% with relative standard deviation of 2.4% and 2.6% respectively.

키워드

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