Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Hwao-tang on Superoxide Generation and Neutrophil Functions

  • Park Soo Young (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim Han Geu (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee Soo Kyung (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Ahan Jong Chan (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Chung Tae Wook (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Moon Jin-Young (Department of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Park Sun Dong (Department of Prescription, College of Oriental Medicine, Dongguk University) ;
  • Kim June Ki (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Choi Dall Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim Cherl Ho (Department of Biochemistry, College of Oriental Medicine, Dongguk University) ;
  • Park Won Hwan (Department of Diagnostics, College of Oriental Medicine, Dongguk University)
  • Published : 2003.02.01
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Abstract

We investigated that Hwao-tang had various effects on stimulus-induced superoxide generation in human neutrophils. Hwao-tang significantly inhibited N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation in a concentration-dependent manner, but not that induced by arachidonic acid. Also, Hwao-tang significantly reduced mouse paw oedema induced by carrageenan. The results suggest that protein tyrosine kinase participates in fMLP-mediated superoxide generation by Hwao-tang-treated human neutrophils. Also, the results indicate that Hwao-tang exerts anti-inflammatory effects related to the inhibition of neutrophil functions and of NO and prostaglandin E2 production, which could be due to a decreased expression of iNOS and COX-2.

Keywords

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