Effects of the Renal Function of Complex Herbal Medication in 20 Diabetic Nephropathy Patients

당뇨병성 신증 환자 20예에서 복합한약전탕액이 신기능에 미치는 영향

  • Choi Woo-Jung (Department of Internal Medicine, School of Oriental Medicine, Wonkwang University) ;
  • Kim Dong-Woung (Department of Internal Medicine, School of Oriental Medicine, Wonkwang University) ;
  • Shin Sun-Ho (Department of Internal Medicine, School of Oriental Medicine, Wonkwang University) ;
  • Lee Un-Jung (Department of Internal Medicine, School of Oriental Medicine, Wonkwang University) ;
  • Choi Jin-Young (Department of Internal Medicine, School of Oriental Medicine, Wonkwang University) ;
  • Shin Hak-Soo (Department of Internal Medicine, School of Oriental Medicine, Wonkwang University) ;
  • Cho Gwon-Il (Department of Internal Medicine, School of Oriental Medicine, Wonkwang University) ;
  • Lee Kwang-Souk (Department of Internal Medicine, School of Oriental Medicine, Wonkwang University)
  • 최우정 (원광대학교 한의과대학 내과학교실) ;
  • 김동웅 (원광대학교 한의과대학 내과학교실) ;
  • 신선호 (원광대학교 한의과대학 내과학교실) ;
  • 이언정 (원광대학교 한의과대학 내과학교실) ;
  • 최진영 (원광대학교 한의과대학 내과학교실) ;
  • 신학수 (원광대학교 한의과대학 내과학교실) ;
  • 조권일 (원광대학교 한의과대학 내과학교실) ;
  • 이광석 (원광대학교 한의과대학 내과학교실)
  • Published : 2003.04.01

Abstract

Diabetic Nephropathy is one of the major causes of chronic renal failure. It is a common microvascular complication and clinically defined as the presence of persistent Proteinuria. We studied the effects and change of the renal function of Complex Herbal medication of the 20Diabetic Nephropathy patients. We measured the initial levels of Total Protein, Creatinine Clearance Rate(Ccr), Serum Creatinine(Serum-Cr), Urine Creatinine(Urine-Cr) and HbA1C on admission and followed up the level changes of Total Protein, Ccr, Serum-Cr and Urine-Cr on discharge. The results are following : Complex Herbal Medication does not cause the renal toxicity. The longer hypertension period is, the higher Serum-Cr level and Urine-Cr level. In an older age group, Urine-Cr is lower. 4.From the 'Deficiency in Origin and Excess in Superficiality(本虛表實)'points of view, Complex Herbal Medication improves the Serum-Cr in Diabetic Nephropathy patients. According to this results, it could be suggested that Complex Herbal Medication does not cause the renal toxicity in Diabetic Nephropathy patients and intensive controls of blood sugar, blood pressure and Complex Herbal Medication prevent the renal failure in Diabetic Nephropathy patients with early stage of Microalbumiuria.

Keywords

References

  1. 내분비학 민헌기;최영길;고창순;허갑병;이태희;이홍규
  2. current opinion nephrology and hypertention v.10 no.4 Evolving stratergies for renoprotection: Diabetic nephropathy. Parving. Hans-Henrik;Hovind. Prter;Rossing Kasper;Andersen. Steen. https://doi.org/10.1097/00041552-200107000-00006
  3. 당뇨병성 혈관합병증 진단과치료 최영길;이태희;신순현;김영섭
  4. 황제내경소문 장은암;마원대
  5. 내분비대사병증치정요 이가경;전연령
  6. 성제총록 조효충
  7. 대한한의학회지 v.19 no.2 소갈의 전변증과 당뇨병의 만성 합병증에 대한 비교고찰 강석봉
  8. 중서의결합당뇨병학 임란
  9. 임상경험집 축심여
  10. 동의보감 허준
  11. 중국당뇨병방치특색 교언빈
  12. 해리슨내과학 Kurt J. Isselbacher;Eugene Braunwald;Tean D. Willson;Joseph B. Martin;Anthony S. Fauci;Dennis L. Kasper.
  13. kidney international v.59 no.2 Progression of diabetic nephropathy. Hovind. Peter;Ressing Peter;Tarnow, Lise;Smidt, Ulla M;Parving. Hans-Henrik https://doi.org/10.1046/j.1523-1755.2001.059002702.x
  14. kidney international v.55 no.1 Renal disease and hypertention in non-insulin-dependent diabetes mellitus. Ismail, Nuhad;Beeker, Bryan;Strzelczyk, Piotr;Ritz, Eberhard. https://doi.org/10.1046/j.1523-1755.1999.00232.x
  15. kidney international v.58 no.4 Causes of albuminuria in patiens with type 2 diabetes without diabetic retinopathy. Christensen, Per K;Larsen, Svend;Hom, Thomas;Olsen, Steen; Parving, Hans-Henrik. https://doi.org/10.1046/j.1523-1755.2000.00333.x
  16. 동의신계내과학 두호경
  17. Mosby's Crash Course(Internal medicine). Mosby international Ltd..
  18. N Engl J Med v.311 Predicting diabetic nephropathy in insulin-dependent patients. Mogensen C. E.;Christensen C. K. https://doi.org/10.1056/NEJM198407123110204
  19. N Engl J Med v.310 Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. Mogensen CE https://doi.org/10.1056/NEJM198402093100605
  20. Kidney Int v.31 Microalbuminuria as a predirtor of clinical diabetic nephropathy. Mogensen CE https://doi.org/10.1038/ki.1987.50
  21. 대한한의학회지 v.15 no.1 상용 한약복합 처방의 장기간 연용 투여가 신기능에 미치는 영향에 관한 고찰. 김동웅