Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Chekambohyulansin-tang, a Poly-herbal Formula, on the Obesity rats induced by Ovariectomy

체감보혈안신탕이 난소적출로 유발된 흰쥐의 비만에 미치는 영향

  • Kwon Young Kyu (Department of Physiology, College of Oriental Medicine, Kyungsan University) ;
  • Kang Soon Byung (Department of Pharmacology, College of Oriental Medicine, Kyungsan University) ;
  • Kim Sang Chan (Department of Pharmacology, College of Oriental Medicine, Kyungsan University)
  • 권영규 (경산대학교 한의과대학 생리학교실) ;
  • 강순병 (경산대학교 한의과대학 방제학교실) ;
  • 김상찬 (경산대학교 한의과대학 방제학교실)
  • Published : 2003.04.01
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Abstract

In order to evaluate the effect of Chekambohyulansin-tang (CST) which was a traditional poly-herbal formula has been used for treatment of obesity in Korea, on the obesity in ovariectomized rats, the changes of body weight, peri-kidney, abdominal and perineal subcutaneous fat weight and their histological changes were measured with the detection of number and/or size of adipocytes after an oral administration of CBT extracts (125, 250 and 500 mg/kg, respectively). CBT significantly attenuated elevations in the body weight, the absolute and relative weight of peri-kidney, abdominal and perineal fat tissues and decrease the severe hypertrophy, the number of adipocytes, and the diameter of adipocytes of peri-kidney, abdominal and perineal fat tissues in ovariectomized rats in a dose dependent manner. These results provide a story evidence that CBT can playa role in the treatment of obesity induced by ovariectomy. Determination of the specific mechanisms involred toxicological dosage of CBT on obesity will require addition study.

Keywords

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