Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Protective effect of Ganopoly and Ganopoly/C+ on nephrotoxicity induced by cisplatin in rats

Cisplatin의 신장독성에 대한 영지추출물 복합제제의 보호효과

  • Kim Dae Geun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Kun Jung (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Ju Sung Min (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Yong Ik (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Choi Ho Seung (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Keum Kyung Soo (Department of Oriental Medical Informatics, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim Won Sin (Division of Natural Science & Technology, College of Natural Sciences and Institute of Basic Natural Sciences, WonkWang University) ;
  • Gao Yiu Ai (Institute of Food, Nutrition and Human Health, Auckland, Massey University) ;
  • Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
  • 김대근 (원광대학교 한의과대학 병리학교실) ;
  • 김근중 (원광대학교 한의과대학 병리학교실) ;
  • 주성민 (원광대학교 한의과대학 병리학교실) ;
  • 김용익 (원광대학교 한의과대학 병리학교실) ;
  • 최호승 (원광대학교 한의과대학 병리학교실) ;
  • 금경수 (원광대학교 한의학전문대학원) ;
  • 김원신 (원광대학교 자연과학대학 생명과학기술부) ;
  • 고익괴 (뉴질랜드 마시대학교 식품영양인체건강연구소) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실)
  • Published : 2003.04.01
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Abstract

In this paper, the effect of Ganopoly(extracts of Ganoderma lucidum) and Ganopoly/C+(70% Ganopoly + 30% chitosan) on cisplastin-induced nephrotoxicity was investigated in Sprague-Dawley rats. A single dose of cisplastin(5 ㎎/㎏) kg) was administered intraperitoneally after pretreatment of saline, Ganopoly and Ganopoly/C+ for 7 days. The nephrotoxicity and renal function were manifestated by the changes of body weight, blood pressure, biochemical changes and solute in urine and plasma. After the treatment of CDDP(cis-dichlorodiamineplatinum), a significant elevation of kidney weight, serum urea, cretinine, urine volume for 24 hours, urine magnesium, and a severe or significant decrease in body weight, blood pressure, creatinine clearance, urine osmolarity, serum albumin, etc. The nephrotoxicity was further confirmed by a significant decrease in glutathione S-transferase(GSH) in urine and kidney homogenate, GSH, glutathione peroxidase(GSH-Px) and catalase in kidney tissue. And also the lipid peroxidation was significantly increased in kidney homogenate. These signs of nephrotoxicity was ameliorated by the pretreatment and consecutive administration of Ganopoly and Ganopoly/C+ for 14 days after the Lp. injection of CDDP on 7th day after pretreatment of Ganopoly and Ganopoly/C+. The amelioration of nephrotoxicity was evidenced by significant reduction in serum urea and creatinine concentration, and improvement of other index of renal function. And The activity of antioxidant enzymes were partially recovered in kidney tissue of rats treated by CDDP and the administration of Ganopoly and Ganopoly/C+. These results indicate the cispastin induced nephrotoxicity is due to an impairment of tubular reabsorption systems enhanced by necrosis of proximal tubule, and the Ganopoly and Ganopoly/C+ has a partial protective effect on nephrotoxicity induced by CDDP. The polysacchride of Ganoderma lucidum may improve the therapeutic index of nephrotoxicity induced by CDDP. However, it is needed to elucidate the mechanism for confirming the therapeutic effect.

Keywords

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