Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

A Study on Cytokine Modulating Effect of Three Origins of Phellinus Linteus

산지별 상황버섯의 사이토칸인 조절 효과에 관한 연구

  • Kim Jin Soo (Oriental medical College, Daejeon University) ;
  • Kim Jung Hyo (Nursing college, Chosun University) ;
  • Lee Hyo Jeong (Department of Sports science, Kyunghee University) ;
  • Khil Jae Ho (Department of Sports Science, Kyunghee University) ;
  • Kim Sung Hoon (Department of Oncology, Kyunghee University) ;
  • Kim Dong Hee (Oriental Medical College, Daejeon University)
  • Published : 2003.08.01
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Abstract

Pellinus linteus has been used for the prevention of cancer traditionally. There are three origins of Pellinus linteus, Korea, China and Cambodia. However, their immunological activities were not evlauated comparatively. Thus, this study was done to evaluate immunomodulatory effects of Phellinus linteus(PL) from Korea, china and cambodia, We confirmed PL showed two major protein bands, 50 kDa and 80 kDa by protein analysis. These PL effectively upregulated the expressions of IL-2 at 10 ug/ml and GM-CSF, IL-4, IL-10, IL-12(p35), IL-12(p40), IL-18, IFN-r in all concentrations. However, Korea-PL upregulated the expression of IL-12 more effectively than the other PLs. It intended to increase NO with no significance. Those results indicate Phellinus linteus had cytokine modulating effect

Keywords

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