Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effects on the Type I hypersensitivity and Inflammatory Reaction of Hwanggigunjung-tang

황기건중탕이 알레르기에 미치는 영향

  • Lee Jeong Hoon (Department of Oriental Medicine, Graduate School. Dongeui University) ;
  • Hong Hyun Woo (Department of Oriental Medicine, Graduate School. Dongeui University) ;
  • Gam Chul-woo (Department of Oriental Medicine, Graduate School. Dongeui University) ;
  • Park Dong il (Department of Oriental Medicine, Graduate School. Dongeui University)
  • 이정훈 (동의대학교 한의과대학 폐계내과학교실) ;
  • 홍현우 (동의대학교 한의과대학 폐계내과학교실) ;
  • 감철우 (동의대학교 한의과대학 폐계내과학교실) ;
  • 박동일 (동의대학교 한의과대학 폐계내과학교실)
  • Published : 2003.10.01
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Abstract

HGJT has been used for the treatment of general weakness, digestive organ disease and so on. This study was carried out for the purpose of knowing the inhibitory effect on the Type I hypersensitivity and Inflammatory reactions of Hwanggigunjungtang(HGJT). The reasults were obtained as follows: HGJT(0.1. 0.5. 1, 2mg/g) concentration of dependently inhibited compound48/80 induced anaphylaxis reaction in mice. HGJT(2mg/g) also inhibited permeability of evans blue into peritoneal cavity in mice. HGJT reduced IgE, CRP. WBC and Platelets on egg albumin induced hypersensitivity. But serum NO was grown. According to above results, HGJT may be beneficial in the type I hypersensitivity and Inflammatory reactions by inhibition of histamine release from mast cells.

Keywords

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