International Journal of Vascular Biomedical Engineering
- 제1권1호
- /
- Pages.13-23
- /
- 2003
- /
- 1598-8929(pISSN)
Hemodynamic Characteristics Affecting Restenosis after Percutaneous Transluminal Coronary Angioplasty with Stenting in the Angulated Coronary Stenosis
- Lee, Byoung-Kwon (Department of Internal Medicine, College of Medicine, Inje University, Sanggye Paik Hospital) ;
- Kwon, Hyuck-Moon (Department of Internal Medicine, College of Medicine, Yonsei University) ;
- Roh, Hyung-Woon (Department of Mechanical Engineering, Soongsil University) ;
- Cho, Min-Tae (Department of Mechanical Engineering, Soongsil University) ;
- Suh, Sang-Ho (Department of Mechanical Engineering, Soongsil University)
- 발행 : 2003.04.30
초록
Backgrounds: The present study in angulated coronary stenosis was to evaluate the influence of velocity and wall shear stress (WSS) on coronary atherosclerosis, the changes of hemodynamic indices following coronary stenting, as well as their effect of evolving in-stent restenosis using human in vivo hemodynamic parameters and computed simulation quantitatively and qualitatively. Methods: Initial and follow-up coronary angiographies in the patients with angulated coronary stenosis were performed (n=80). Optimal coronary stenting in angulated coronary stenosis had two models: < 50 % angle changed(model 1, n=43), > 50% angle changed group (model 2, n=37) according to percent change of vascular angle between pre- and post-intracoronary stenting. Flow-velocity wave obtained from in vivo intracoronary Doppler study data was used for in vitro numerical simulation. Spatial and temporal patterns of velocity vector and recirculation area were drawn throughout the selected segment of coronary models. WSS of pre/post-intracoronary stenting were calculated from three-dimensional computer simulation. Results: Follow-up coronary angiogram demonstrated significant difference in the percent of diameter stenosis between two groups (group 1: