Journal of Korean Physical Therapy Science (대한물리치료과학회지)

Korean Physical Therapy Science (대한물리치료과학회)
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Transdermal permeation and Anti-inflammatory Effects of Piroxicam Gel by Phonophoresis

음프록시캄 겔을 이용한 음파영동이 경피투과와 염증에 미치는 효과

  • Choi, Sug-Ju (Dept. of Physical Therapy, Graduate School, Dongshin University) ;
  • Kim, Tae-Youl (Dept. of Physical Therapy, College of Oriental Medicine, Dongshin University) ;
  • Yoon, Se-Won (Dept. of Physical Therapy, Graduate School, Dongshin University)
  • 최석주 (동신대학교 대학원 물리치료학과) ;
  • 김태열 (동신대학교 물리치료학과) ;
  • 윤세원 (동신대학교 대학원 물리치료학과)
  • Published : 2003.03.30
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Abstract

This study was performed that how phonophoresis using ultrasound for piroxicam affects transdermal permeation and anti-inflammative effects. Transdermal permeation study conducted by using hairless mouse had two categories: control group and ultrasound group. Transdermal permeation was observed according to duty cycle and intensity. Anti-inflammatory effects were determined using in Sprague-Dawley rat. The subjects were divided into three groups of six SD rat each 24 hour, 48 hour, 72 hour. The results of this study were as follows: 1. Transdermal permeation of piroxicam was measured according to ultrasound duty cycle. This research demonstrates that ultrasound group retains more transdermal permeation than control group, and that pulsed ultrasound group holds a little more transdermal permeation than continuous ultrasound group. 2. The transdermal permeation of piroxicam is closely related with ultrasound intensity. Effect of each group of transdermal permeation was significant rises in proportion to ultrasound intensity. 3. By observing inflammation of the tissue caused by trauma, phonophoresis group showed more significant of anti-inflammatory effect. The conclusion of phonophoresis was found to improve significantly the transdermal permeation and the anti-inflammatory effect.

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