Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Urinary Profiles of the Endogenous Steroids in Pre-Menopausal Women with Uterine Leiomyoma

자궁근종 성장에 있어서 내인성 성호르몬의 역할

  • Jung, Byung-Hwa (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Bai, Sang-Wook (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
  • Chung, Bong-Chul (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Kim, Sei-Kwang (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
  • Park, Ki-Hyun (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University)
  • 정병화 (한국과학기술 연구원 생체대사 연구센터) ;
  • 배상욱 (연세대학교 의과대학 산부인과학교실) ;
  • 정봉철 (한국과학기술 연구원 생체대사 연구센터) ;
  • 김세광 (연세대학교 의과대학 산부인과학교실) ;
  • 박기현 (연세대학교 의과대학 산부인과학교실)
  • Published : 2003.03.30
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Abstract

목 적: 본 연구의 목적은 내인성 성호르몬이 자궁근종의 성장에 미치는 영향을 알아보고자 연구를 시행하였다. 연구대상 및 방법: 폐경전 자궁근종 환자 27명과 같은 연령대의 정상여성 25명을 대상으로 하였다. 모든 대상군의 여성에서 24시간 소변을 모아서 소변내 estrogen, androgen의 대사체들을 GC-MS를 이용하여 측정하였으며 두 군에서의 차이를 비교분석 하였다. 결 과: 소변내 $17{\beta}$-estradiol, 5-androstene-$3{\beta}$, $16{\beta}$, $17{\beta}$-triol, 11-keto-ethiocholanolone, $11{\beta}$-hydroxy-androsterone, THS, THA, THE, a-cortolone, a-cortol 및 $\beta$-cortol가 환자군에서 의의있게 증가하였으며 $17{\beta}$estradiol/estrone 및 $11{\beta}$-hydroxy-ethiocholanolone/$11{\beta}$-hydroxy-androsterone도 환자군에서 의의있게 증가하였다. 결 론: 자궁근종의 성장은 요중 estrogen과 androgen의 농도와 밀접한 관련이 있으며 이는 환자의 스테로이드 호르몬 대사 감소에 기인한 것으로 사료된다.

Keywords

References

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