대한한의학회지 (The Journal of Korean Medicine)

  • 제24권1호
  • /
  • Pages.155-168
  • /
  • 2003
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

스트레스와 에탄올로 유발된 mouse의 위점막 손상에 대한 귀비탕의 예방효과

The Defensive Effect of Keuibi-tang on the Gastric Mucous Membrane of Mouse Injured by Stress and Ethanol

  • 김학재 (동국대학교 한의과대학 내과학교실) ;
  • 최준혁 (동국대학교 한의과대학 내과학교실) ;
  • 임성우 (동국대학교 한의과대학 내과학교실)
  • 발행 : 2003.03.01
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초록

This study was carried out to investigate the effect of Keuibi-tang (KBT) on the injury of gastric mucous membrane by stress and ethanol in mice. The normal group was non-inflammation elicited mice. The two control groups were mice with gastro-inflammation elicited by stress and ethanol. The two sample groups were mice administered KBT before gastro-inflammation elicitation. In the common morphology and histochemical change, the two control groups were observed with various injuries such as hemorrhagic erosion and ulcer, while the sample group was the same as the normal group. In the immunohistochemical change, the distributions of PNA and COX-1 treated with KBT noticeably increased over the control group (P<0.05). The distributions of $NF-{\kappa}B$ p50, COX-2 and TUNEL in the group treated with KBT were noticeably lower than in the control group (P<0.05). The distribution of KBT was the same as the normal group. According to the above results, it is supposed that KBT is applicable to gastritis and gastric ulcer due to stress and alcoholic drinks.

키워드

참고문헌

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