Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Genetic Polymorphism of Vascular Endothelial Growth Factor (VEGF C936T) in the Korean Population

  • Kim, Jin-Kyeoung (Graduate School of Life Science and Biotechnology, Pochon CHA University) ;
  • Oh, Do-Yeun (Institute for Clinical Research, Pochon CHA University) ;
  • Kwak, Sun-Young (Institute for Clinical Research, Pochon CHA University) ;
  • Han, Jin-Hee (Institute for Clinical Research, Pochon CHA University) ;
  • Chung, Young-Sun (Department of Neurosurgery, College of Medicine, Pochon CHA University) ;
  • Kim, Nam-Keun (Institute for Clinical Research, Pochon CHA University)
  • Published : 2003.09.01
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Abstract

Leiden), no mutation was detected in either group. Allele frequencies of A2379G and G2391 A mutations were not significantly different between CAD patients and controls. Non-Caucasian populations have a considerably lower factor Ⅴ Leiden allele frequency than Caucasian populations. Thus, it may be due to differences in the genetic background as well as environmental factors.

Keywords

References

  1. Awata T, Inoue K, Kurihara S, Ohkubo T, Watanabe M, Inukai K, Inoue I, and Katayama S (2002) A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes 51: 1635-1639 https://doi.org/10.2337/diabetes.51.5.1635
  2. Faviana P, Boldrini L, Spisni R, Berti P, Galleri D, Biondi R, Camacci T, Materazzi G, Pingitore R, Miccoli P, and Fontanini G (2002) Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression. Oncol Rep 9: 617-620
  3. Iruela-Arispe ML and Dvorak HF (1997) Angiogenesis: a dynamic balance of stimulators and inhibitors. Thromb Haemost 78: 672-677
  4. Kang BY, Kim KT, Eo HS, Lee KH, Hong SS, Shin JH, and Lee CC (2000) Association between genetic variation of the insulin receptor gene and essential hypertension in the Korean population. Korean J Biol Sci 4: 87-90 https://doi.org/10.1080/12265071.2000.9647528
  5. Kang BY, Kim HH, and Lee KO (2003) The Pstl polymorphism of the human apolipoprotein Al gene in Korean elite athletes. Korean J Biol Sci 7: 69-73 https://doi.org/10.1080/12265071.2003.9647685
  6. Kim NK, Kang GD, Kim HJ, Kim SH, Nam YS, Lee S, Chung HM, Kang SH, Ahn JY, Choi BO, Hwang SG, and Oh D (2002) Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) in healthy Korean. Korean J Genet 24: 227-234
  7. Ladoux A and Frelin C (1993) Expression of vascular endothelial growth factor by cultured endothelial cells from brain microvessels. Biochem Biophys Res Commun 194: 799-803 https://doi.org/10.1006/bbrc.1993.1892
  8. La Rosa S, Uccella S, Finzi G, Albarello L, Sessa F, and Capella C (2003) Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features. Hum Pathol 34: 18-27 https://doi.org/10.1053/hupa.2003.56
  9. Maloney JP, Silliman CC, Ambruso DR, Wang J, Tuder RM, and Voelkel NF (1998) In vitro release of vascular endothelial growth factor during platelet aggregation. Am J Physiol 275: H1054-H1061
  10. Mazure NM, Chen EY, Yeh P, Laderoute KR, and Giaccia AJ (1996) Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res 56: 3436-3440
  11. Mermod N, Williams TJ, and Tjian R (1988) Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature 332: 557-561 https://doi.org/10.1038/332557a0
  12. Renner W and Pilger E (1999) Simultaneous in vitro quantitation of vascular endothelial growthfactor mRNA splice variants. J Vasc Res 36: 133-138 https://doi.org/10.1159/000025636
  13. Renner W, Kotschan S, Hoffmann C, Obermayer-Pietsch B, and Pilger E (2000) A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. J Vasc Res 37: 443-448 https://doi.org/10.1159/000054076
  14. Scandurro AB and Beckman BS (1998) Common proteins bind mRNAs encoding erythropoietin, tyrosine hydroxylase, and vascular endothelial growth factor. Biochem Biophys Res Commun 246: 436-440 https://doi.org/10.1006/bbrc.1998.8639
  15. Senger DR, Van de Water L, Brown LF, Nagy JA, Yeo KT, Yeo TK, Berse B, Jackman RW, Dvorak AM, and Dvorak HF (1993) Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev 12: 303-324 https://doi.org/10.1007/BF00665960
  16. Senger DR, Perruzzi CA, Streit M, Koteliansky VE, de Fougerolles AR, and Detmar M (2002) The alpha(1)beta(1) and alpha(2) beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol 160: 195-204 https://doi.org/10.1016/S0002-9440(10)64363-5
  17. Shahbazi M, Fryer AA, Pravica V, Brogan IJ, Ramsay HM, Hutchinson IV, and Harden PN (2002) Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol 13: 260-264
  18. Uthoff SM, Duchrow M, Schmidt MH, Broil R, Bruch HP, Strik MW, and Galandiuk S (2002) VEGF isoforms and mutations in human colorectal cancer. Int J Cancer 101: 32-36 https://doi.org/10.1002/ijc.10552
  19. Vuorela P, Carpen O, Tulppala M, and Halmesmaki E (2000) VEGF, its receptors and the tie receptors in recurrent miscarriage. Mol Hum Reprod 6: 276-282 https://doi.org/10.1093/molehr/6.3.276