Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)
- Volume 23 Issue 4
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- Pages.131-134
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- 2003
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- 1225-6307(pISSN)
Variability in Drug Interaction According to Genetic Polymorph isms in Drug Metabolizing Enzymes
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Jang, In-Jin
(Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital) ;
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Yu, Kyung-Sang
(Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital) ;
- Cho, Joo-Youn (Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital) ;
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Chung, Jae-Yong
(Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital) ;
- Kim, Jung-Ryul (Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital) ;
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Lim, Hyeong-Seok
(Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital) ;
- Shin, Sang-Goo (Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital)
- Published : 2003.12.01
Abstract
There are significant differences in the extent of drug interactions between subjects. The influence of the genetic make up of drug metabolizing enzyme activities (CYP3A5, CYP2C19 and UDP-glucuronosyl transferase) on the pharmacokinetic drug interaction potential were studied in vivo. Nineteen healthy volunteers were grouped with regard to the