Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inhibitory Effects of Glycine on Morphine-Induced Hyperactivity, Reverse Tolerance and Postsynaptic Dopamine Receptor Supersensitivity in Mice

  • Shin, Kyung-Wook (Department of Manufacturing Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Hong, Jin-Tae (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Yoo, Hwan-Soo (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Song, Sukgil (Department of Manufacturing Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Oh, Ki-Wan (Department of Pharmacy, College of Pharmacy, Chungbuk National University)
  • Published : 2003.11.01
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of glycine on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice was examined. A single administration of morphine (10 mg/kg, s.c.) induced hyperactivity as measured in mice. The morphine-induced hyperactivity was inhibited by pretreatment with glycine (100, 200 and 400 mg/kg, i.p.). In addition, it was found repeated administration of morphine (10 mg/kg, s.c.) to mice daily for 6 days caused an increase in motor activity which could be induced by a subsequent morphine dose, an effect known as reverse tolerance or sensitization. Glycine (100, 200 and 400 rng/kg, i.p.) also inhibited morphine-induced reverse tolerance. Mice that had received 7 daily repeated administrations of morphine also developed postsynaptic dopamine receptor supersensitivity, as shown by enhanced ambulatory activity after administration of apomorphine (2 mg/kg, s.c.). Glycine inhibited the development of postsynaptic dopamine receptor supersensitivity induced by repeated administration of morphine. It is suggested that the inhibitory effects of glycine might be mediated by dopaminergic (DAergic) transmission. Accordingly, the inhibition by glycine of the morphine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity suggests that glycine might be useful for the treatment of morphine addiction.

Keywords

References

  1. Allen, R. M. and Young S. J., Phencyclidine-induced psychosis. Am. J., Psychiatry, 135, 1081-1084 (1978) https://doi.org/10.1176/ajp.135.9.1081
  2. Babbini, M. and Davis W. M., Time-dose relationships for locomotor activity effects of morphine after acute or repeated treatment. Br. J., Pharmacol., 46, 213-224 (1972)
  3. Bhargava, H. N., Cyclo (Leu-Gly) inhibits the development of morphine-induced analgesic tolerance and dopamine receptor supersensitivity in rat. Life Sci., 27, 117-123 (1980) https://doi.org/10.1016/0024-3205(80)90452-X
  4. Bhargava, H.N. and Matwyshyn G. A. Dizocilpine (MK-801) blocks tolerance to the analgesic but also the hyperthermic effect of morphine in the rat. Pharmacol., 47, 344-350 (1993) https://doi.org/10.1159/000139117
  5. Daniel, C. J., Andrea, B., Henry, S., and Abel L., Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors. Biol. Psychiatry, 45, 668-679 (1999) https://doi.org/10.1016/S0006-3223(98)00237-6
  6. John, R. M. and Takemori, A. E., Chronically administered morphine increases dopamine receptoe sensitivity in mice, Eur. J. Pharmacol., 121, (1986) https://doi.org/10.1016/0014-2999(86)90493-0
  7. Johnson, J. W. and Ascher, P., Glycine potentiates the NMDA response in cultured mouse brain. Nature, 325, 529-531 (1987) https://doi.org/10.1038/325529a0
  8. Kim, H. S., Kim, K. S., and Oh K. W., Inhibition by ginsenosides Rb1 and Rg1 of cocaine-induced hyperactivity, conditioned place preference, and postsynaptic dopamine receptor supersensitivity in mice, Pharmacol. Biochem. Behav., 63(3), 407-412 (1999) https://doi.org/10.1016/S0091-3057(99)00020-9
  9. Kuribara, H. and Tadokoro, S., Reverse tolerance to ambulation-increasing effects of methamphetamine and morphine in 6 mouse strains. Jpn. J. Pharmacol., 49, 197-203 (1989) https://doi.org/10.1254/jjp.49.197
  10. Kuschinski, K. and Hornykiewicz, O., Effect of morphine on striatal DA metabolism: Possible mechanism of its opposite effect on locomotor activity in rats and mice. Eur. J. Pharmacol., 26, 41-50 (1974) https://doi.org/10.1016/0014-2999(74)90072-7
  11. Lutfy, K. Hurlbut, D. E. and Weber, E., Blockade of morphineinduced analgesia and tolerance in mice by MK-801. Brain Res., 616, 83-88 (1993) https://doi.org/10.1016/0006-8993(93)90195-S
  12. Puri, S. K. and Lal, H., Effect of dopaminergic stimulation or blockade on morphine-withdrawal aggression. Psychopharmacol., 32, 113-120 (1973) https://doi.org/10.1007/BF00428682
  13. Ritzmann, R. F., Bhargava, H. N., and Flexner, L. B., Blockade of narcotic-induced dopamine receptor supersensitivity by cyclo (Leu-Gly). Proc. Natl. Acd. Sci. USA, 76, 5997-5998 (1979) https://doi.org/10.1073/pnas.76.11.5997
  14. Robinson, T. and Becker, J., Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res. Rev., 396, 157-198 (1986) https://doi.org/10.1016/0165-0173(86)90002-0
  15. Trujillo, K. A. and Akil, A., Inhibition of morphine tolerance and dependence by NMDA receptor antagonist MK-801. Science, 251, 85-87 (1991) https://doi.org/10.1126/science.1824728
  16. Woo, S. H., Kim, H. S., Yun, J. S., T., Lee, M. K., Oh, K. W., Seong, Y. H., Oh, S., and Jang C. G., Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity. Pharmacol. Res., 43 (4), 335-340 (2001) https://doi.org/10.1006/phrs.2000.0789
  17. Yoon, I. S., Kim, H. S., Hong, J. T., Lee, M. K, and Oh, K. W., Inhibition of muscimol on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. Pharmacol., 65, 204-209 (2002) https://doi.org/10.1159/000064345