Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Hypocholesterolemic Property of Yucca schidigera and Quillaja saponaria Extracts in Human Body

  • Kim, Sang-Woo (Division of Endocrinology & Metabolism, Department of Medicine, Miz Medi Hospital) ;
  • Park, Sang-Kyu (Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology) ;
  • Kang, Sung-Il (Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology) ;
  • Kang, Han-Chul (Research Center of Celltechs Co.) ;
  • Oh, Han-Jin (Department of Family Medicine, Samsung Cheil General Hospital, Sungkyunkwan University of Medicine) ;
  • Bae, Chul-Young (Department of Family Medicine, Bundang Cha General Hospital, Phochon Jungmoon University of Medicine) ;
  • Bae, Dong-Ho (Department of Applied Biology & Chemistry, Konkuk University)
  • Published : 2003.11.01
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Abstract

This study was undertaken to observe the effects of the blend of partially purified Yucca schidigera and Quillaja saponaria extracts on cholesterol levels in the human's blood and gastrointestinal functions, and to determine if a new cholesterol-lowering drug can be developed by the further purification of the extracts. Ultrafiltration and sequential diafiltration increased the amounts of steroidal saponin in aqueous yucca extract and terpenoid saponin in aqueous qullaja extract from 9.3% and 21.4% to 17.2% and 61.8%, respectively. Taking 0.9 mg of the blend (6:4, v:v) of the resulting filtrates a day for 4 weeks resulted in the decreases in total and LDL cholesterol levels in blood plasma of hyper-cholestrolemic patients with enhancement in gastrointestinal symptoms of patients.

Keywords

References

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