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The Pharmaceutical Society of Korea (대한약학회)
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Effect of Active Synthetic 2-Substituted Quinazolinones on Anti-Platelet Aggregation and the Inhibition of Superoxide Anion Generation by Neutrophils

  • Chang, Fang-Rong (Graduate Institute of Natural Products, Kaohsiung Medical University) ;
  • Wu, Chin-Chung (Graduate Institute of Natural Products, Kaohsiung Medical University) ;
  • Hwang, Tsong-Long (Graduate Institute of Natural Products, Chang Gung University) ;
  • Patnam, Ramesh (Graduate Institute of Natural Products, Kaohsiung Medical University) ;
  • Kuo, Reen-Yen (Graduate Institute of Natural Products, Kaohsiung Medical University) ;
  • Wang, Wei-Ya (Graduate Institute of Natural Products, Kaohsiung Medical University) ;
  • Lan, Yu-Hsuan (Graduate Institute of Natural Products, Kaohsiung Medical University) ;
  • Wu, Yang-Chang (Graduate Institute of Natural Products, Kaohsiung Medical University)
  • Published : 2003.07.01
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Abstract

Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.

Keywords

References

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