Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Lidocaine Intoxication: Two Fatal Cases

  • Lee, Sang-Ki (National Institute of Scientific Investigation) ;
  • Lee, Soo-Yeun (National Institute of Scientific Investigation) ;
  • In, Sang-Whan (Southern District Office, National Institute of Scientific Investigation) ;
  • Choi, Hwa-Kyung (National Institute of Scientific Investigation) ;
  • Lim, Mi-Ae (National Institute of Scientific Investigation) ;
  • Chung, Kyu-Hyuck (College of Pharmacy, Sungkyunkwan University) ;
  • Chung, Hee-Sun (Southern District Office, National Institute of Scientific Investigation)
  • Published : 2003.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

We present two fatal cases, a 41-year-old male (case 1) and his 8-year-old daughter (case 2), resulting from acute lidocaine poisoning. Lidocaine was quantified by gas chromatography (GC) analysis using nitrogen-phosphorus detection. The lidocaine concentrations of cases 1 and 2 were: liver, 27.7 $\mu$ g/g and 24.9 $\mu$g/g; spleen, 70.1 $\mu$g/g and 29.9 $\mu$g/g; and gastric contents, 23.6 $\mu$g/g and 42.8 $\mu$g/g, respectively.

Keywords

References

  1. Baselt, R. C., Disposition of Toxic Drugs and Chemicals in Man, $5^{th}$ Ed. Chemical Toxicology Institute, Foster city, CA, pp. 469-470, (2000)
  2. Baselt, R. C., Disposition of Toxic Drugs and Chemicals in Man, $5^{th}$ Ed. Chemical Toxicology Institute, Foster city, CA, pp.471, (2000)
  3. Chung, H. S., Kim, E. M., Kim, M. D., and Kim, M. K., Fatal zipeprol concentration in 65 poisoning cases. Annual Report of N.I.S.I., 28, 325-332 (1996)
  4. Dawling, S., Flanagan, R. J., and Widdop, B., Fatal lignocaine poisoning: report of two cases and review of the literature. Hum. Toxicol., 8, 389-392 (1989) https://doi.org/10.1177/096032718900800512
  5. Engelhart, D. A., Lavins, E. S., Hazenstab, C. B., and Sutheimer, C. A., Unusual death attributed to the combined effects of chloral hydrate, lidocaine, and nitrous oxide. J. Anal. Toxicol., 22, 246-247 (1998) https://doi.org/10.1093/jat/22.3.246
  6. Hino, Y., Inoue, H., Kudo, K., Nishida, N., and Ikeda, N., Distribution of tetracaine and its metabolite in rabbits after high versus normal spinal anesthesia. Forensic. Sci. Int., 124, 130-136 (2001) https://doi.org/10.1016/S0379-0738(01)00585-0
  7. Nancarrow, C., Rutten, A. J., Runciman, W. B., Mather, L. E., Carapetis, R. J., McLean, C. F., and Hipkins. S. F., Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep. Anesth. Analg., 69, 276-283 (1989)
  8. Polkis, A., Mackell, M. A., and Tucker, E. F., Tissue distribution of lidocaine after fatal accidental injection. J. For. Sci., 29, 1229-1236 (1984)
  9. Physicians desk reference, 56 edition, Medical Economic Company, Inc. pp.655, (2002)
  10. Sakata, K., Ishigaki, S., and Sakata, M., Distribution of lidocaine and disopyramide in human blood and tissue, A case report of death caused by spinal anesthesia. Forensic. Sci. Int., 37, 1-10 (1988) https://doi.org/10.1016/0379-0738(88)90101-6
  11. Sawaguchi, A., Sawaguchi, T., and Ohue, O., A case of lidocaine poisoning. poster presentations, XXXV TIAFT Annual Meeting, 1997
  12. Shimizu, K., Shiono, H., Matsubara, K., Awaya, T., Takahashi, T., Saito, O., Ogawa, K., Mizukami, H., Uezono, T., and Akutsu, H., The tissue distribution of lidocaine in acute death due to overdosing. Legal Med., 2, 101-105 (2000) https://doi.org/10.1016/S1344-6223(00)80032-2
  13. Winek, C. L., Reliability of 22-hour postmortem blood and gastric alcohol samples. J. Am. Med. Assoc., 233, 912 (1975)