Archives of Pharmacal Research

  • 제26권4호
  • /
  • Pages.270-274
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  • 2003
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Synthesis and Cytotoxicity of New 3-Alkyl-1-(1-methyl-2-phenylethyl)ureas Related to Ceramide

  • Lim, Sejin (College of Pharmacy, Dongduk Women s University) ;
  • Ryu, Jae-Hark (College of Pharmacy, Chung-Ang University) ;
  • Im, Chaeuk (College of Pharmacy, Chung-Ang University) ;
  • Yim, Chul-Bu (College of Pharmacy, Chung-Ang University)
  • 발행 : 2003.04.01
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초록

A series of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide was synthesized and evaluated for their in vitro cytotoxic activity against five human tumor cell lines. The urea analogue (2b) of 813 showed comparable or slightly more potent cytotoxic activity as compared to B13, indicating that urea does appear to serve as a bioisostere of amide.

키워드

참고문헌

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