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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Evaluation of Cytotoxicity of Stilbene Analogues

  • Lee, Sang-Kook (College of Pharmacy, Ewha Womans University) ;
  • Nam, Kyung-Ae (College of Pharmacy, Ewha Womans University) ;
  • Hoe, Yeon-Hoi (College of Pharmacy, Ewha Womans University) ;
  • Min, Hye-Young (College of Pharmacy, Ewha Womans University) ;
  • Kim, Eun-Young (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Ko, Hyojin (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Song, Soyoung (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Lee, Taeho (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Kim, Sanghee (Natural Products Research Institute, College of Pharmacy, Seoul National University)
  • Published : 2003.04.01
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Abstract

Resveratrol analogs were newly synthesized and evaluated for cytotoxicity in cultured human lung and colon cancer cells. 3,5,4-Trimethoxy-trans-stilbene and 3,5,2',4'-tetramethoxy-trans-stilbene were found to be more potent rather than resveratrol. 3,4,5-Trimethoxy-4'-bromo-cis-stilbene was the most active among the test compounds.

Keywords

References

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