YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Topoisomerase I Inhibition of 2-Substituted 5-Nitrobenzimidazoles

2 위치가 치환된 5-니트로 Benzimidazole 유도체들의 Topoisomerase I 억제 활성

  • ;
  • Edmond J. LaVoie (College of Pharmacy, Rutgers the State University of New Jersey, USA) ;
  • 권민진 (동서대학교 생명공학과) ;
  • ;
  • 김정선 (동서대학교 생명공학과)
  • Published : 2003.06.01
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Abstract

A series of 2-phenyl-5-nitrobenzimidazoles substituted at the para positon of the 2-phenyl moiety was synthesized ＆ evaluated for their activity to inhibit topoisomerase I. The structure-activity relationship study revealed that neither the electronic nor lipophilic parameters were related to the topoisomerase I inhibition. A strict spatial requirement seems to be present for retention of topoisomerase I inhibition activity.

Keywords

References

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