YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Comparisons of Antidiabetic Activities between White Ginseng Ethanol Extract and IH-901 in Streptozotocin-Induced Diabetic Rats

Streptozotocin 유발 당뇨 흰쥐에서 백삼 에탄올엑스와 IH-901의 항당뇨 작용 비교

  • 고성권 (중앙대학교 인삼산업연구센터) ;
  • 성종환 ((주) 일화 중앙연구소) ;
  • 최용의 (중앙대학교 인삼산업연구센터) ;
  • 이충렬 (중앙대학교 인삼산업연구센터) ;
  • 박경수 (경희대학교 약학대학) ;
  • 정성현 (경희대학교 약학대학)
  • Published : 2003.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Antidiabetic activities of white ginseng 50％ ethanol extract (WGE) and IH901, an intestinal metabolite of ginsenoside R $b_1$, were compared in multiple low dose streptozotocin (STZ)-induced diabetic rats. WGE or IH901 were coadministered with STZ on Day 1 at dose of 100 and 300 mg or 10 and 30 mg, respectively, and continually administered for 16 days. STZ dissolved in citrate boner was injected intraperitoneally at dose of 20 mg/kg for 5 consecutive days. During the experiment, plasma glucose level and body weight were measured every 4$^{th}$ day. Amount of food and water intake were evaluated once a week and compared between groups. WGE and IH901 both significantly reduced the plasma glucose levels on Day 16 as compared with those of the diabetic control group. In the meantime, amount of food and water intake in WGE-and IH901-treated groups were significantly improved in a dose dependent fashion as compared with those of the diabetic control group. Taken together WGE and IH901 showed the comparable antidiabetic activities at the corresponding doses used in this experiment.

Keywords

References

  1. 한국약품식물자원도감 육창수
  2. 현대 본초학 육창수
  3. Pharm, Bull. v.22 Studies on the saponins of ginseng. I. Structure of ginsenoside-$R_0$, $R_1$, $R_2$ and $R_c$, $R_d$ Sanata, S.;Kondo, N.;Shoji, J.;Tanaka, O.;Shibata, S. https://doi.org/10.1248/cpb.22.421
  4. Yakugaku Zasshi. v.107 Chemical studies in crude drug processing. V. On the constituents of ginseng and red ginseng radox ribra (2): Comparison of the constityents of white ginseng and red ginseng prepared from the same Panax ginseng root Kitagawa, I.;Taniyama, T.;Shibuya, H.;Nota, T.;Yoshikawa, M. https://doi.org/10.1248/yakushi1947.107.7_495
  5. J. Pharm, Dyn. v.4 Effects of hypoglycemic components in Ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas Kimura, M.;Waki, L.;Chujo, T.;Kikuchi, T.;Hiyama, C.;Yamazaki, K.;Tanaka, O. https://doi.org/10.1248/bpb1978.4.410
  6. Chem. Pharm. Bull. v.33 Studies on the mechanism of the hypoglycemic activity of ginsenosideRb₂in streptozotocin-diabetic rats Yokozawa, Kobayashi, T.;Oura, H.;Kawashima, Y. https://doi.org/10.1248/cpb.33.869
  7. 약학회지 v.29 인삼 담백질의 방사선 방어작용 김춘미;한규선
  8. 화한약백과도감 난파항웅
  9. 고려인삼학회지 v.20 고려인삼의 화학성분에 관한 고찰 박종대
  10. Panata Medica v.61 Reversal of daunomycin and vinblastine resistance in multidrug-resistant P338 leukemia in vitro through enhanced cytotoxicity by triterpenoids Hasegawa, H.;Sung, J. H.;Matsumiya, S.;Uchiyama, M.;Inouye, Y.;Kasai, R.;Yamasaki, K. https://doi.org/10.1055/s-2006-958126
  11. 생약학회지 v.26 사람의 장내세균에 의한 인삼 사포닌의 대사 성종환;장곡천수부;송궁지지;내산이수;하주영;이문순;허재두
  12. Planta Medica v.62 Main Ginseng saponin metabolites fromed by intenal bacteria Hasegawa, H.;Sung, J. H.;Matsumiya, S.;Uchiyama, M. https://doi.org/10.1055/s-2006-957938
  13. 생약학회지 v.28 사람의 장내세군에 의하 사포닌의 대사 (제2보) 성종환;장곡천수부;하주영;박세호;송궁지지;내산아수;허재두
  14. Journal of Traditional Medicines v.14 Metabolixm of Ginseng saponins by human intestinal bacteria, and isolation and identification of bacteria associated with the metabolism Hasegawa, H.;Sung, J. H.;Matsumiya, S.;Unchiyama, M.
  15. Journal of Traditional Medicines v.14 Pharmacodynamic analysis of Ginseng saponin metabolites formed by human intestinal bacteria Hasegawa, H.;Sung, J. H.;Matsumiya, S.;Unchiyama, M.
  16. Archives of Pharmacal Research v.20 Ginseng intestinal bacterial metabolite IH901 as a new anti-metastatic agent Hasegawa, H.;Sung, J. H.;Huh', J. D. https://doi.org/10.1007/BF02975208
  17. Planta Medica v.64 In vitro antigenotoxic of novel Ginseng sapoin metabolites fromed by intestinal bacteria Lee, B. H.;Lee, S. J.;Hui, J. H.;Lee, S. J.;Moon, C. K. https://doi.org/10.1055/s-2006-957501
  18. Cancer Letters v.144 Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenodcarcinoma cells resistant to cisplatin Lee, S. J.;Sung, J. H.;Lee, S. J.;Moon. C. K.;Lee, B. H. https://doi.org/10.1016/S0304-3835(99)00188-3
  19. Journal of Traditional Medicines v.17 An intestinal bacterial metabolite (MI) of ginseng protopanaxadiol saponins inhibits tumor-induced noevascularization Suda, K.;Murakami, K.;Murata, J.;Haswgawa, H.;Saiki, I.
  20. Biochemical Pharmacology v.60 Induction of apoptosis by a novel intestinal metabolite of Ginseng sponin via cytochrome cmediated activation of caspase-3 protease Lee, S. J.;Ko, W. G.;Kim, J. H.;Sung, J. H.;Lee, S. J.;Moon, C. K.;Lee, B. H. https://doi.org/10.1016/S0006-2952(00)00362-2
  21. Diabetes Res. Clin. Pract v.99 Piogletazone prevents mice from multiple low-does streptozotocin-induced insulitis and diabetes Takamura, T.;Ando, H.;Nagai, Y.
  22. 약학논총 v.7 인삼류생약의 항당뇨에 관한 비교연구 (인삼류 엑스가 Streptozotocin 유발 고혈당 흰쥐에 미치는 영향 고성권;황완균;김일혁
  23. 中葯大辭典 岡漁新醫學員