약학회지 (YAKHAK HOEJI)

  • 제47권1호
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  • Pages.14-19
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  • 2003
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  • 0377-9556(pISSN)
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  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

모발생장기 유도 C3H 생쥐에 있어서 미녹시딜과 생약추출 혼합 조성물의 모발 재성장 유도 효능

Evaluation of the Herbal Extract Mixture for the Effects of Hair-Regrowth Compared to 3％ Minoxidil; Elongation of Anagen Period on C3H Mice

  • 이계호 (STC 생명과학연구원 신약개발연구소) ;
  • 한선일 (STC 생명과학연구원 신약개발연구소) ;
  • 박길흥 (고려대학교 의과대학) ;
  • 권영이 (STC 생명과학연구원 신약개발연구소)
  • 발행 : 2003.02.01
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초록

The hair cycle consists of three phases, growth (anagen), involution (catagen) and quiescence (telogen) phases. In order to evaluate hair re-growth effect of herbal extracts mixture containing the 70％ ethanol extracts of Polygoni Multiflori Radix, Mori Cortex Radicis, Gingko Biloba Folium and Pine bud, we have examined the induction of the anagen phase and/or elongation of the anagen period using C3H mice. Morphological examination was done by Hattori' and Ogawa's method. Enzyme activities of ${\gamma}$-glutamyl transpeptidase (${\gamma}$-GT) and alkaline phosphatase (ALP) was detected by Bessey-Lovry-Brock's method. Enzyme activity as a biochemical marker of hair cycle was investigated in the third hair cycle period of C3H mice after depilation. 3％ Minoxidil treated group and herbal extract mixture treated group were shown 3 days earlier initiation of anagen than control group. In cycling mouse skin, ${\gamma}$-GT activity is pronounced during anagen and greatly diminished during telogen. Herbal extract mixture has shown promising hair re-growth effect on hair follicular cycles of C3H mice.

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참고문헌

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