대한한의학회지 (The Journal of Korean Medicine)

  • 제24권3호
  • /
  • Pages.51-64
  • /
  • 2003
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  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

노령 흰쥐의 뇌허혈 손상시 뇌대사활성의 변화 및 량격산화탕의 영향에 대한 [$^{14}C$2-Deoxyglucose Autoradiography 연구

Alteration of Neural Activity and Effect of Yanggyuksanhwa-tang(Lianggesanhuo-tang) on Cerebral Ischemia of Aged BCAO Rats; [$^{14}C$]2-Deoxyglucose Autoradiography Study

  • 손철훈 (경희대학교 한의과대학 해부학교실) ;
  • 신정원 (경희대학교 동서의학대학원 신경과학교실) ;
  • 손영주 (경희대학교 동서의학대학원 신경과학교실) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실) ;
  • 원란 (경희대학교 동서의학대학원 신경과학교실) ;
  • 손낙원 (경희대학교 동서의학대학원 신경과학교실)
  • Sohn, Cheol-Hoon (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Shin, Jung-Won (Department of Neuroscience, Graduate School of East-West Medical Science Kyung Hee University) ;
  • Sohn, Young-Joo (Department of Neuroscience, Graduate School of East-West Medical Science Kyung Hee University) ;
  • Jung, Hyuk-Sang (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Won, Ran (Department of Neuroscience, Graduate School of East-West Medical Science Kyung Hee University) ;
  • Sohn, Nak-Won (Department of Neuroscience, Graduate School of East-West Medical Science Kyung Hee University)
  • 발행 : 2003.09.01
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초록

Objective : This study investigated the alteration of neural activity and effect of Yanggyuksanhwa-tang (Lianggesanhuo-tang) on cerebral ischemia of rats. Methods : Considering age-related impact on cerebral ischemia, aged rats (18 months old) were used for this study. Ischemic damage was induced by the transient occlusion of bilateral common carotid arteries (BCAO) with hypotension. Yanggyuksanhwa-tang (Lianggesanhuo-tang) was administered twice a day orally. Then alterations of neural activities in the brain of aged BCAO rats were measured by the [$^{14}C$]2-deoxyglucose autoradiography method. Results : The BCAO in aged rats led to significant decrease of neural activity in the whole brain. Treatment with Yanggyuksanhwa-tang (Lianggesanhuo-tang) significantly attenuated the decrease of neural activity in the whole brain following BCAO ischemia. Treatment significantly attenuated the decrease of neural activity in the CA1, CA2, CA3, dentate gyrus of the hippocampus, activated barrel, barrel cortex, somatosensory cortex, cingulate cortex, caudate putamen, and medial septal nucleus following BCAO in aged rats. Treatment with Yanggyuksanhwa-tang (Lianggesanhuo-tang) also significantly attenuated the decrease of neural activity in the anteroventral thalamic nucleus, ventral anterior thalamic nucleus, arcuate nucleus, posterior hypothalamic area, medial mammillary nucleus, lateral periaqueductal gray, dorsal raphe nucleus, interpeduncular nucleus, median raphe nucleus, and medial pontine nucleus. Conclusion : It can be suggested that Yanggyuksanhwa-tang (Lianggesanhuo-tang) has a neuroprotecuve effect on cerebral ischemia through the control of glucose metabolic rate and cerebral blood flow.

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