대한의생명과학회지 (Biomedical Science Letters)
- 제9권4호
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- Pages.241-248
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- 2003
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Sodium Salicylate Activates p38MAPK Though a Specific-Sensing Mechanism, Distinct from Pathways Used by Oxidative Stress, Heat Shock, and Hyperosmotic Stress
- Kim, Jung-Mo (Department of Molecular Biology, College of Natural Sciences and Research Institute of Genetic Engineering, Pusan National University) ;
- Oh, Su-Young (Department of Molecular Biology, College of Natural Sciences and Research Institute of Genetic Engineering, Pusan National University) ;
- Kim, Min-Young (Department of Molecular Biology, College of Natural Sciences and Research Institute of Genetic Engineering, Pusan National University) ;
- Seo, Myoung-Suk (Department of Molecular Biology, College of Natural Sciences and Research Institute of Genetic Engineering, Pusan National University) ;
- Kang, Chi-Duk (Department of Biochemistry, College of Medicine, Pusan National University) ;
- Park, Hye-Gyeong (Department of Molecular Biology, College of Natural Sciences and Research Institute of Genetic Engineering, Pusan National University) ;
- Kang, Ho-Sung (Department of Molecular Biology, College of Natural Sciences and Research Institute of Genetic Engineering, Pusan National University)
- 발행 : 2003.12.01
초록
Sodium salicylate, a plant stress hormone that plays an important role(s) in defenses against pathogenic microbial and herbivore attack, has been shown to induce a variety of cell responses such as anti-inflammation, cell cycle arrest and apoptosis in animal cells. p38MAPK plays a critical role(s) in the cell regulation by sodium salicylate. However, the signal pathway for sodium salicylate-induced p38MAPK activation is yet unclear. In this study, we show that although sodium salicylate enhances reactive oxygen species (ROS) production, N-acetyl-L-cysteine, a general ROS scavenger, did not prevent sodium salicylate-induced p38MAPK, indicating ROS-independent activation of p38MAPK by sodium salicylate. Sodium salicylate-activated p38MAPK appeared to be very rapidly down-regulated 2 min after removal of sodium salicylate. Interestingly, sodium salicylate-pretreated cells remained fully responsive to re-induction of p38MAPK activity by a second sodium salicylate stimulation or by other stresses,