Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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The Frequency of MSI in Un selected Korean Colorectal Adenocarcinomas

  • Ryu, Hye-Myung (Department of Pathology, Kyoung Pook National University Hospital) ;
  • Lee, Myung-Hoon (Department of Pathology, Kyoung Pook National University Hospital) ;
  • Bae, Han-Ik (Department of Pathology, Kyoung Pook National University Hospital)
  • Published : 2003.09.01
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Abstract

Microsatellite instability (MSI), which is caused by a deficient mismatch repair system, is seen in most of the hereditary non-polyposis colon cancers (HNPCC) and a portion of sporadic colorectal cancers. Forty unselected colorectal cancer patients were analyzed for MSI using silver stain plus kit. The overall incidence of MSI in studied cases was 17％ (7/40). The incidence is similar result with previous study. MSI in colorectal carcers was more prevalent in moderative differentiated adenocarcinoma than well differentiated adenocarcinoma

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