Biomolecules & Therapeutics

  • 제11권3호
  • /
  • Pages.190-195
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  • 2003
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지

Genotoxicity Study of AS6, a Triterpenoid Derivatives

  • Kwon, Jung (R＆D Center of Dong Kook Pharmaceutical Co., LTD.,) ;
  • Lee, Michael (R＆D Center of Dong Kook Pharmaceutical Co., LTD.) ;
  • Cha, Kyung-Hoi (R＆D Center of Dong Kook Pharmaceutical Co., LTD.) ;
  • Kim, Jong-Choon (Department of Pharmacology and Toxicology, College of Veterinary Medicine Chonnam National University) ;
  • Han, Jung-Hee (Korea Institute of Toxicology, KRICT)
  • 발행 : 2003.09.01
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초록

To assess the genotoxicity of AS6, several classical toxicological tests were performed. In Ames test, AS6 did not show any transformation of revertant with or without S-9 metabolic activating system, indicating the lack of mutagenic effect of the compound. To assess clastogenic effect, in vivo micronucleus and in vitro chromosomal aberration assays were performed using male ICR mice and Chinese hamster lung (CHL) fibroblast cells, respectively. Chromosomal aberration was not induced regardless of the presence of S-9 metabolic activating system. In addition, AS6 did not cause any increase in the incidence of micronucleated polychromatic erythrocytes at any of the dose levels, suggesting little clastogenicity in vitro or in vivo. Taken together, these results demonstrate that AS-6 has no mutagenic effect in our test system.

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참고문헌

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