Biomolecules & Therapeutics

  • 제11권2호
  • /
  • Pages.119-125
  • /
  • 2003
  • /
  • 1976-9148(pISSN)
  • /
  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지

Influence of Bornyl Acetate on Blood Pressure and Aortic Strips Contractility of the Rat

  • Lim, Dong-Yoon (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Ki, Young-Woo (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Na, Gwang-Moon (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Kang, Moo-Jin (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Kim, Byeoung-Cheol (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Kim, Ok-Min (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Hong, Soon-Pyo (Department of Internal Medicine (Cardiology), College of Medicine, Chosun University)
  • 발행 : 2003.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The present study was conducted to investigate the effects of bornyl acetate on arterial blood pressure and vascular contractile responses in the normotensive rats and to establish the mechanism of action. Both phenylephrine (an adrenergi$\alpha$-receptor agonist) and high potassium (a membrane-depolarizing agent) caused greatly contractile responses in the isolated aortic strips. These phenylephrine (10$^{-5}$ M)-induced contractile responses were depressed in the presence of high concentrations of bornyl acetate (10∼20 $\mu\textrm{g}$/ml), but not affected in low concentrations of bornyl acetate (2.5∼5$\mu\textrm{g}$/ml). High potassium (5.6 ${\times}$ 10$^{-2}$ M)-induced contractile responses were also greatly inhibited in the presence of bornyl acetate (2.5∼20 $\mu\textrm{g}$/ml) in a dose-dependent fashion. Bornyl acetate (1∼10 mg/kg) given into a femoral vein of the normotensive rat produced a dose-dependent depressor response, which is transient (data not shown). Interestingly, the infusion of a moderate dose of bornyl acetate (3mg/kg/30 min) made a significant reduction in pressor responses induced by intravenous norepinephrine. Collectively, these results obtained from the present study demonstrate that intravenous bornyl acetate causes a dose-dependent depressor action in the anesthetized rat at least partly through the blockade of adrenergic $\alpha$$_1$-receptors. bornyl acetate also causes vascular relaxation in the isolated aortic strips of the rat via the blockade of adrenergic $\alpha$$_1$-receptors, in addition to the unknown mechanism of direct vasorelaxation.

키워드

참고문헌

  1. Ablad, B., Borg, K.O., Carlsson, E., Johnson, G., Malmfors, L. and Regardh, C.G. (1975). A survey of the pharmacological properties of meioprolol in animals and man. Acta. Pharmacol. Toxicol. (Copenh) 36(5), 7-23
  2. Bevan, J. A. (1982). Selective action of diltiazem on cerebral vascular smooth muscle in the rabbit: antagonism of extrinsic but not intrinsic maintained tone. Am. J. Cardiol. 46, 519-524
  3. Bolton, T. M. (1979). Mechanisms of action of transmitters and other substances on smooth muscle. Physiol. Rev. 3,606-718
  4. Chiou, L. C., Ling, J.Y. and Chang, C.C. (1997). Chinese herb constituent a$^{^}$-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices. Neurosci. Lett. 231,171-174 https://doi.org/10.1016/S0304-3940(97)00557-0
  5. Constantine, J. W, Mcshane, W.K., Scriabine, A. and Hess, H.J. (1973). Analysis of the hypotensive action of prazosin. In Hypertension: Mechanisms and Management (Ed. by Onesti, G., Kim, K. E. and Moyer, J.H.), pp.429. New York: Grume & Stratton Inc
  6. Dubc, G. P., Baik, Y H. and Schwartz, A. (1985). Effects of novel calcium channel agonist dihydropyridine analogue, Bay K 9644, on pig coronary artery: Biphasic mechanical response and paradoxical potentiation of contraction by diltiazem and nimodipine, J. Cardiovasc. Pharmacol. 7, 377-389 https://doi.org/10.1097/00005344-198503000-00025
  7. Dube, G. P., Baik, Y. H., Van Breemen, C. and Schwanz, A. (1988). Effects of isosorbidc dinitrate and diltiazeru on Ca$^{2+}$ flux and comracrion in artery. European J. Pharmacol. 145, 39-47 https://doi.org/10.1016/0014-2999(88)90346-9
  8. Fleckenstein, A. (1977). Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Ann. Rev. Pharmacol. Toxicol. 17, 149-166 https://doi.org/10.1146/annurev.pa.17.040177.001053
  9. Freis, E. E., Mackey, J. D. and Oliver,W F. (1951). The effect of 'sympatholytic' drugs on the cardiovascular responses to epinephrine and norepinephrine in man. Cir: Res. 3, 254
  10. Imai, S. and Kitagawa. (1981). A comparison of the differential effects of nitroglycerin, nifedipine, and papaverine on contractures induced in vascular and intestinal smooth muscle by potassium and lanthanum. Jap. J. Pharmacol. 31, 193 https://doi.org/10.1254/jjp.31.193
  11. Ito, Y, Kitamura, K. and Kuriyama, H. (1998a). Actions of nitroglyccrin on the membrane and mechanical properties of smooth muscles of the coronary artery of the pig. Br 1. Pharmacol. 70, 197-202
  12. Ito, Y., Kitamura, K. and Kuriyama, H. (1980). Nitroglycerin and catecholamine actions on smooth muscle cells of cannine coronary artery. J. Physiol. (London) 309, 171-183 https://doi.org/10.1113/jphysiol.1980.sp013502
  13. Kim, J. M., Park, K. O. and Baik, Y. H. (1989). Effects of antiepileptic drugs on contractile responses of vascular smooth muscles. Chonnam J. Med. Sci. 2(1), 50-59
  14. Schwartz, A. and Taira, N. (1983). Calcium channel-blocking drugs: A novel intervention for the treatment of cardiac disease. Cire. Res. (American Heart association Monograph) 52, 1-183 https://doi.org/10.1161/01.RES.52.1.1
  15. Schwartz, A. and Triggle, D. J. (1984). Cellular action of calcium blocking drugs. Ann. Rev. Med. 35, 325-339 https://doi.org/10.1146/annurev.me.35.020184.001545
  16. Tachikawa, E., Takahashi, M. and Kashimoto, T. (2000). Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem. Pharmacal. 60, 433-440 https://doi.org/10.1016/S0006-2952(00)00343-9
  17. Tallatida, R. J. and Murray, R. B. (1987). Manual of pharmacologic calculation with computer programs. 2nd Ed New York Speringer- Verlag 132
  18. Wada, A., Takara, E., Izumi, F., Kobayashi, H. and Yanagihara, N. (1985). Influx of $^{22}$Na through acetylcholine receptor-associated Na channels: relationship between $^{22}$Na influx, $^{45}$Ca influx and secretion of catecholamines in cultured bovine adrenal medullary cells. Neuroscience 15, 283-292 https://doi.org/10.1016/0306-4522(85)90135-6
  19. Watanabe, K., Goto, Y. and Yoshitomi, K. (1973). Central depressant effects of the extracts of magnolia cortex. Chem. Pharm. Bull. (Tokyo) 21, 1700-1708 https://doi.org/10.1248/cpb.21.1700
  20. Watanabe, K., Watanabe, H., Goto, Y., Yamaguchi, M., Yarnamoto, N. and Hagino, K. (1983). Pharmacological properties of magnolol and honokiol extracted from magnolia officinalis: Central depressant effects. Plania. Med. 49, 103-108 https://doi.org/10.1055/s-2007-969825
  21. Watkins, R. W. and Davidson, I. W. F. (1980). Comparative effects of nitroprusside and nitroglycerin: Actions on phasic and tonic Components of arterial smooth muscle contraction. European J. Pharmacol. 62, 191-200 https://doi.org/10.1016/0014-2999(80)90275-7